Drugs online research references
J Clin Psychiatry. 1983 May;44(5 Pt 2):79-81.
Metabolism and kinetics of bupropion.
Schroeder DH.
Studies of bupropion in rats, dogs, and normal volunteers showed that bupropion was rapidly and completely absorbed, widely distributed in tissues, and metabolized extensively prior to its excretion. Metabolism in rats and dogs appeared to be predominantly by side chain oxidative cleavage, while reduction of the intact parent aminoketone to an aminoalcohol was an additional major pathway in man. Most of the metabolites were excreted in urine. Bupropion, but not its metabolites, was concentrated in many tissues, with a brain to plasma ratio of about 25:1. Plasma protein binding of bupropion (75%-80%) did not seem to limit its tissue distribution. Bupropion was found to be a weak to moderate inducer of drug metabolism.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6406469&dopt=Abstract
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Pharmacol Biochem Behav. 1983 May;18(5):737-40.
Bupropion, d-amphetamine, and amitriptyline-induced conditioned taste aversion in rats: dose effects.
Miller DB, Miller LL.
Nine groups of rats (n = 6 per group) were adapted to a daily one-half hour period of water availability. When intake had stabilized, they were allowed access to a 0.1% (w/v) solution of saccharin, and immediately afterward were given IP injections of isotonic saline; bupropion HCl (10.0, 20.0, or 40.0 mg/kg); d-amphetamine-sulfate (0.5, 1.0, 2.0 mg/kg); or amitriptyline HCl (5.0, 10.0, or 20.0 mg/kg) in a volume of 1 ml. The lowest dose of each compound as chosen to be equipotent in screening tests used to identify potential antidepressants. Following 2 days of access to water alone, all groups were given a choice between water and saccharin for 3 consecutive days. All compounds induced taste aversions in a dose-related manner, but amitriptyline induced greater and longer-lasting aversions than either bupropion or d-amphetamine which were equipotent over the dose range studied. As such, this is the first demonstration that bupropion and amitriptyline, two clinically effective antidepressants, can induce taste aversions and replicates as well the common finding that d-amphetamine has substantial taste aversion-inducing properties. The ability of these compounds to induce taste aversions could be mediated through their effects on central catecholaminergic processes although amitriptyline has significant peripheral anticholinergic effects.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6407035&dopt=Abstract
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J Clin Psychiatry. 1984 Jul;45(7 Pt 2):29-36.
Delineation of anxiety and phobic disorders responsive to monoamine oxidase inhibitors: implications for classification.
Sheehan DV.
Studies of the treatment of panic anxiety and various other states with monoamine oxidase (MAO) inhibitors are critically reviewed. It is concluded that MAOIs have differential effects on several dimensions of pathologic anxiety. The association between depression and anxiety states is also reviewed; it is observed that MAOIs effectively treat severe anxiety and phobic disorders without operating strictly via their antidepressant mechanism. In addition, it is proposed that biologic depression and biologic anxiety should be considered to have some independence from one another. Guidelines for the clinical delineation of anxiety disorders are provided, and the clinical and research implications of the proposal for revision of DSM-III anxiety and phobic disorders section, are outlined in detail. It is suggested that anxiety and phobic disorders be classified into endogenous (disease) and exogenous (nondisease) types.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6429129&dopt=Abstract
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