Drugs online research references
Neurosci Biobehav Rev. 1985 Summer;9(2):283-97.
Activity of dopamine-containing substantia nigra neurons in freely moving cats.
Trulson ME.
The present series of studies examined the activity of presumed dopamine-containing neurons in the substantia nigra of freely moving cats. These neurons were found to have a slow (1-9 spikes/sec) discharge rate, unusually long duration action potentials (2-4 msec) and frequently fired in bursts with progressive decreases in the amplitude of the action potential within the burst. These neurons showed no significant change in their activity across the sleep-waking cycle, and showed no changes in activity with phasic movement. Most units were unresponsive to olfactory, noxious, tactile, auditory and visual stimulation, when unit activity was integrated over several seconds following stimulus presentation. However, phasic auditory and visual stimuli produced a period of excitation lasting approximately 120 msec after a delay of about 80 msec. The period of excitation was followed by a period of inhibition lasting approximately 60 msec. Presumed dopamine-containing substantia nigra units showed no significant circadian changes in activity. The firing rates of these units were inhibited by dopamine agonists, including the direct-acting agonist, apomorphine, the dopamine precursor, L-dihydroxyphenylalanine, a dopamine releasing agent, d-amphetamine, and a dopamine reuptake blocker, bupropion, and were excited by a dopamine receptor blocker, haloperidol. Thus, these neurons show many similarities to dopamine units recorded in anesthetized rats; however, they showed several notable differences as well. Recording the activity of these units in behaving animals allows one to examine behavioral correlates of unit activity. Furthermore, the data (sensory stimulation, pharmacological, etc.) obtained in the unanesthetized preparation are far more relevant to the physiological and pharmacological effects that may occur in humans.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3925396&dopt=Abstract
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Farmaco [Sci]. 1985 Aug;40(8):608-16.
Behavioral and eegraphic changes induced by dopaminergic antidepressants in rabbits.
Bo P, Patrucco M, Savoldi F, Formigli L, Manzo L.
Nomifensine, Bupropion and Amineptine, "second generation" antidepressants with dopaminergic effects, were studied in the rabbit with special regard to their action on somatic and autonomic behavior, and cerebral electrical activity. All three drugs induced an "alarm" reaction and typical dopaminergic behavioral responses including sniffing, jumping and chewing. Mydriasis was also observed especially at high dose levels. EEG showed an arousal pattern for each of these drugs. A marked increase in the hippocampal spiking resulted from the i.v. administration of 15 mg/kg of Bupropion.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3930287&dopt=Abstract
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Clin Pharmacol Ther. 1985 Nov;38(5):586-9.
Pharmacokinetics of bupropion and its major basic metabolites in normal subjects after a single dose.
Laizure SC, DeVane CL, Stewart JT, Dommisse CS, Lai AA.
The pharmacokinetics of bupropion (BUP) and its three major basic metabolites (the erythroamino alcohol [EB], the threoamino alcohol [TB], and the hydroxy [HB] metabolites) were characterized after a single, oral, 200 mg dose of BUP in six healthy men. Twenty-one sequential plasma samples for analysis by HPLC were drawn from each subject over the 56-hour period after dosing. Pharmacokinetic analyses were by noncompartmental methods. The mean elimination t1/2 values of BUP, TB, EB, and HB were 9.8, 19.8, 26.8, and 22.2 hours, respectively. The mean plasma AUCs of TB and HB were 2.4 and 10.3 times greater, respectively, than that for BUP. Because of the substantial presence of these metabolites in systemic circulation, further studies are recommended to understand further their roles in the clinical profile of this new antidepressant.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3931955&dopt=Abstract
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