Drugs online research references
Biull Eksp Biol Med. 1990 Dec;110(12):629-30.
[GABAergic modulation of amnesic trace reproduction by activation of the dopaminergic system]
[Article in Russian]
Dubrovina NI, Parkhomenko RI, Il'iuchenok RIu.
Features of amnesia trace reactivation by activation of different links of dopaminergic system synaptic apparatus following the change of benzodiazepine, GABAA and GABAB receptors activity are found in experiments in mice. Diazepam pretreatment increases bupropion effectiveness, prolongs duration of enhanced passive avoidance response retrieval during D-1 and D-2 receptors activation by (+)3-PPP and decreases both characteristics under selective D-2 receptor activation by quinpirole. Activation of GABAA and GABAB receptors induces the attenuation of quinpirole effect and the duration of (+)3-PPP action.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1982083&dopt=Abstract
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J Pharm Pharmacol. 1990 Nov;42(11):799-801.
Phenytoin-bupropion interaction: effect on plasma phenytoin concentration in the rat.
Tekle A, al-Khamis KI.
Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Kingdom of Saudi Arabia.
The effect of coadministration of bupropion (50 mg kg-1, p.o.) on the disposition profile of phenytoin has been studied in the rat. Plasma phenytoin concentration was measured serially for 10 h by HPLC. Bupropion had little or no effect on the pharmacokinetic parameters of an acutely administered dose of phenytoin. Following multiple doses of phenytoin however (i.e. steady state) the coadministration of bupropion resulted in significant increases in the elimination half-life (t 1/2), the area under the plasma concentration-time curve (AUC) and the time to maximum plasma concentration (tmax). Allowing for the limitations of single dose studies, these results point to a possible pharmacokinetic interaction between bupropion and phenytoin--the clinical significance of which needs to be assessed.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1982306&dopt=Abstract
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Life Sci. 1990;46(20):PL17-21.
High affinity dopamine reuptake inhibitors as potential cocaine antagonists: a strategy for drug development.
Rothman RB.
Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, MD 20892.
The addictive and euphorogenic effects of cocaine are thought to result primarily from inhibition of dopamine reuptake. Although the potency of cocaine-like drugs as inhibitors of DA reuptake is highly correlated with their potency as reinforcers in animals, several potent DA reuptake blockers (bupropion, nomifensine, benztropine, and mazindol) have not been reported to produce addiction or euphoria in humans. Based on these observations in humans, DA reuptake inhibitors are classified into two groups; type 1 blockers, which produce addiction and euphoria, and type 2 blockers, which do not. Given that type 1 and type 2 blockers act at the same site (the DA transporter), the author suggests that type 2 agents may antagonize the effects of cocaine, and might prove useful in the treatment of cocaine addiction.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2111866&dopt=Abstract
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