Drugs online research references
Am J Emerg Med. 1996 Sep;14(5):456-8.
Analysis of sertraline-only overdoses.
Klein-Schwartz W, Anderson B.
Maryland Poison Center, Department of Pharmacy Practice and Science, University of Maryland School of Pharmacy, Baltimore 21201, USA.
Sertraline is an antidepressant for which preliminary data suggest a low inherent toxicity. Previously reported case series have included coingestants or had small numbers of patients. This study was undertaken to determine the toxicity of overdoses of sertraline alone. A 2-year retrospective and 6-month prospective study was conducted at a regional poison center. There were 52 patients with a mean age of 19.3 +/- 13.8 years and a mean dose of 727 +/- 686 mg. There were no symptoms in 34 cases. Symptomatic patients experienced mild central nervous system, cardiovascular, and gastrointestinal effects. Two patients developed bradycardia which resolved without therapy. While all but 3 of 38 adolescents and adults were treated in a health care facility, 10 of 14 children were managed at home. Gastrointestinal decontamination was performed in 37 cases. No other specific therapy was required. Serious toxicity would not be expected following sertraline-only overdoses.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8765108&dopt=Abstract
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Ned Tijdschr Geneeskd. 1996 Jul 13;140(28):1467-8.
[Extrapyramidal disorders following sertraline use; experiences with a new selective antidepressant]
[Article in Dutch]
Kolling P, Jansen Steur EN, de Burlet HM.
Twents Psychiatrisch Ziekenhuis Helmerzijde, Enschede.
In five patients, two women aged 40 and 65 years and three men aged 42, 70 and 84 years, extrapyramidal symptoms such as rigidity and tremors, were considered to be caused by the use of the antidepressant drug sertraline, a serotonin reuptake inhibitor. After discontinuation of the medication the symptoms disappeared.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8766773&dopt=Abstract
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J Affect Disord. 1996 Jun 5;38(2-3):97-111.
A comparison of the cost-effectiveness of sertraline versus tricyclic antidepressants in primary care.
Forder J, Kavanagh S, Fenyo A.
Personal Social Services Research Unit (PSSRU), London School of Economics, UK.
There has been considerable debate concerning the cost-effectiveness of selective serotonin re-uptake inhibitors (SSRIs) versus tricyclic antidepressants (TCAs) thus far using crude prescription price comparisons or reductionist decision-analytic models. This paper employs a retrospective quasi-experimental design where data on service utilisation, use of medication and informal care were collected for two groups of patients in general practice settings. The mean cost of treatment was marginally greater for those people receiving TCA medication due to greater use of psychiatric services. Factors such as age, previous depression and concomitant physical illness are all associated with greater treatment costs. Further analysis using a prospective design is recommended.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8791179&dopt=Abstract
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