Drugs online research references
Biull Eksp Biol Med. 1990 Sep;110(9):287-9.
[Increase of the number of bone marrow T-suppressor cells under inhibition of immunogenesis during changes of the activity of the neuromediator system]
[Article in Russian]
Idova GV, Cheido MA, Al'perina EL.
Increase of serotoninergic system activity and blockade of dopaminergic system activity led to the change of T- and B-lymphocyte distribution in immunocompetent organs of non-immunized animals. Increase of suppressor cel number with Lyt2.2 phenotype was found in bone marrow of C57Bl/6 mice under activation of serotoninergic system (blockade of serotonin reuptake by sertraline) as well as under blockade of dopaminergic system by administration of dopamine autoreceptor agonist--3-PPP. Role of bone marrow in neuro-immunomodulation is discussed.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1980087&dopt=Abstract
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Psychopharmacology (Berl). 1991;103(3):297-305.
Sertraline and cocaine-induced locomotion in mice. I. Acute studies.
Reith ME, Wiener HL, Fischette CT.
Center for Neurochemistry, N.S. Kline Institute for Psychiatric Research, New York, NY 10035.
The present study assessed the behavioral and pharmacokinetic interaction between the serotonin uptake blocker sertraline and cocaine in C57BL/6ByJ mice. Pretreatment with sertraline (1-32 mg/kg IP) did not affect the total amount of spontaneous locomotor activity during 50 min following administration of cocaine (15-40 mg/kg IP). At doses of sertraline (16 and 32 mg/kg) much higher than those found to inhibit ex vivo neuronal uptake of serotonin by 50% (1-2 mg/kg), the peak of cocaine-induced locomotor activity was shifted towards a later time. A similar effect was seen after pretreatment with serotonin uptake blockers other than sertraline, and also after desipramine. Sertraline (16 and 32 mg/kg), given 60 min prior to cocaine, did not affect levels of cocaine in brain and plasma, and cocaine administration did not alter the brain level of sertraline. Although female mice were more responsive to cocaine than male mice, they were not different in their response to sertraline.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2057535&dopt=Abstract
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Psychopharmacology (Berl). 1991;103(3):306-13.
Sertraline and cocaine-induced locomotion in mice. II. Chronic studies.
Reith ME, Fischette CT.
Center for Neurochemistry, N.S. Kline Institute for Psychiatric Research, New York, NY 10035.
The effects of repeated treatment with the serotonin uptake blocker sertraline on cocaine-induced locomotion in female C57BL/6ByJ mice were examined in three paradigms. First, when animals were treated for 2 weeks with a daily injection of 8 mg/kg IP of sertraline (or placebo) and challenged with cocaine (25 mg/kg IP) 1 h after the final sertraline injection, their cocaine-induced locomotion was the same as that of placebo-pretreated controls. Second, animals were treated for 2 weeks with cocaine (25 mg/kg IP once a day) (or saline) and then for 2 weeks with sertraline (8 mg/kg IP once a day) (or placebo). Locomotion induced by cocaine (25 mg/kg IP) administered 1 h after the final sertraline (placebo) injection was higher in cocaine- than saline-pretreated mice (sensitization), but there was no difference between sertraline- and placebo-pretreated animals. Third, daily treatment with sertraline (8 mg/kg IP) did not change the locomotor stimulatory effect of cocaine (25 mg/kg IP) administered after a 3-week continuous infusion of cocaine (22 mg/kg/day SC) by osmotic minipumps or after three, four, or seven injections of cocaine (15 or 25 mg/kg IP). After cocaine administration (25 mg/kg IP), animals pretreated repeatedly with sertraline (8 mg/kg IP once a day for 2 weeks) had the same plasma or brain levels of cocaine as those pretreated with placebo; there was no difference between cocaine- and saline-treated mice in brain levels of sertraline or desmethylsertraline.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2057536&dopt=Abstract
word match zoloft online literature
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