Drugs online research references
Eur J Pharmacol. 1998 Jan 19;342(1):51-4.
Effects of imipramine and sertraline on protein kinase activity in rat frontal cortex.
Tadokoro C, Kiuchi Y, Yamazaki Y, Oguchi K, Kamijima K.
Department of Psychiatry, School of Medicine, Showa University, Tokyo, Japan.
Three-week administration of sertraline or imipramine to rats (10 mg/kg, intraperitoneally, twice a day) increased ex vivo cyclic AMP-dependent protein kinase activity in the soluble but not in the particulate fraction of the frontal cortex. However, cyclic AMP-dependent protein kinase activity was not affected in either fraction of the parietotemporal cortex and hippocampus. Neither antidepressant altered protein kinase C activity in the soluble and particulate fractions or Ca2+/calmodulin-dependent protein kinase II activity in the frontal cortex. Therefore, sertraline and imipramine both selectively enhance cyclic AMP-dependent protein kinase activity in the frontal cortex. This enhancement might be involved in their biochemical mechanisms.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9544792&dopt=Abstract
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Actas Luso Esp Neurol Psiquiatr Cienc Afines. 1998 Jan-Feb;26(1):17-21.
[Response to sertraline in adolescents with obsessive-compulsive disorder]
[Article in Spanish]
Rodriguez-Ramos P, Mardomingo Sanz MJ.
Servicio de Salud Mental, Comunidad de Madrid.
Previous studies have revealed that serotonin reuptake inhibitors are effective for the treatment of obsessive compulsive disorder (OCD) in children and adolescents. The clinical efficacy of sertraline (STL) for eight adolescents with OCD is examined. The patients are between 12 and 17 years old, being 3 of them female and 6 male. The severity is measured with OC-NIMH Scale and self-report Leyton-20 questionnaire. Administration of STL was begun at 50-200 mg/day, with maintenance dose of 50-150 mg/day. Seven patients responded adequately to STL for more than six months; a girl, aged 16, require discontinuation of STL because of untoward effects. The improvement starts before the 8th week of treatment. Six months later improvement scores with OC-NIMH and Leyton-20 rated near the 50%. In the seven patients with STL either have no untoward effects or mild effect. Favorable results are observed either in adolescents who received STL and cognitive therapy or those with STL as main treatment without any structure psychotherapy. After 6-21 months with STL, improvement has continue of has been increased.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9549132&dopt=Abstract
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Eur J Pharmacol. 2000 Mar 3;390(3):275-85.
Characterization of D-fenfluramine-induced hypothermia: evidence for multiple sites of action.
Cryan JF, Harkin A, Naughton M, Kelly JP, Leonard BE.
Department of Pharmacology, National University of Ireland, Galway, Ireland.
The effects of D-fenfluramine on core body temperature has been largely investigated under conditions of either high or low ambient temperature, whereas little research has focused on this response under normal environmental conditions. Moreover, there has been neglect in research on the mechanisms underlying changes in body temperature. In this study, we demonstrate that D-fenfluramine (5 and 10 mg/kg) induces a sustained decrease in body temperature in the rat under normal ambient temperatures. Pre-treatment with the selective serotonin reuptake inhibitor sertraline (5 mg/kg), the full 5-HT(1A) receptor antagonist 4-fluoro-N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-2-pyridinyl benzamide], WAY 100635 (0.15 mg/kg) and the 5-HT(2C) receptor antagonist benzofuran-2-carboxamidine, RO 43-0440 (2.5 mg/kg) blocked D-fenfluramine-induced hypothermia. Depletion of 5-hydroxytryptamine (5-HT) stores following treatment with the serotonergic neurotoxin parachlorophenylalanine reversed the initial hypothermic effects of D-fenfluramine but not the later effects, as D120 min post-challenge) in animals pre-treated with parachlorophenylalanine. Such findings are consistent with a requirement for D-fenfluramine uptake into 5-HT neurons followed by release of 5-HT from intracellular stores and stimulation of post-synaptic 5-HT receptors to reduce body temperature. The hypothermic response to D-fenfluramine was potentiated by ketanserin pre-treatment 30 min post-challenge but then antagonized at later time intervals. Pre-treatment with the dopamine, D(2) antagonist, haloperidol (1 mg/kg) and sulpiride (30 mg/kg) had a similar effect in blocking the hypothermia as WAY 100635, suggesting a role for dopamine D(2) receptors in the response. Pre-treatment with the alpha(2)-adrenoceptor antagonist yohimbine failed to block the hypothermic response. These results suggest multiple sites of action mediating D-fenfluramine-induced hypothermia and may be the result of a combined effect of D-fenfluramine and its active metabolite norfenfluramine affecting not only the release of 5-HT but also stimulation of post-synaptic receptors.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10708734&dopt=Abstract
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