Drugs online research references
Antimicrob Agents Chemother. 1991 Aug;35(8):1672-3.
Synergistic activity of azithromycin and gamma interferon in murine toxoplasmosis.
Araujo FG, Remington JS.
Department of Immunology and Infectious Diseases, Palo Alto Medical Foundation, Palo Alto, California 94301.
A dose of 75 mg of azithromycin per kg of body weight per day combined with a dose of 2 micrograms of gamma interferon per day and administered for 10 days protected at least 40% of mice infected with a lethal inoculum of Toxoplasma gondii. Azithromycin administered alone protected less than 10% of the mice; gamma interferon had no protective effect.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1656872&dopt=Abstract
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Biopharm Drug Dispos. 1991 Oct;12(7):505-14.
Pharmacokinetics of azithromycin after single oral dosing of experimental animals.
Davila D, Kolacny-Babic L, Plavsic F.
Pliva Research Institute, Laboratory of Experimental Medicine, Zagreb, Yugoslavia.
Azithromycin, a macrolide antibiotic with an enhanced antimicrobial spectrum, was found to have a longer half-life than erythromycin, with marked tissue penetration. The pharmacokinetics of azithromycin after oral administration were compared with those of erythromycin in rats (200 mg kg-1) and rabbits (80 mg kg-1). Concentrations of azithromycin in liver, lung, kidney, ileum, and brain were higher than serum concentrations. The slow decline in tissue concentrations was evident from the biphasic elimination profile. Thus, advantageous pharmacokinetic properties and the broader antimicrobial spectrum of azithromycin relative to erythromycin appear to further support its therapeutic potential.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1657238&dopt=Abstract
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Antimicrob Agents Chemother. 1991 Sep;35(9):1917-8.
In vitro susceptibilities of Campylobacter jejuni and Campylobacter coli to azithromycin and erythromycin.
Taylor DE, Chang N.
Department of Medical Microbiology and Infectious Diseases, University of Alberta, Edmonton, Canada.
MICs of azithromycin and erythromycin for 20 Campylobacter coli and 20 Campylobacter jejuni strains were determined. The results demonstrated that, for Campylobacter species, all high-level erythromycin-resistant strains were also resistant to azithromycin and that azithromycin did not exhibit increased potency in comparison with that of erythromycin.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1659309&dopt=Abstract
word match zithromax online literature
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