Drugs online research references
Genitourin Med. 1995 Aug;71(4):244-6.
Azithromycin levels in cervical mucus and plasma after a single 1.0g oral dose for chlamydial cervicitis.
Worm AM, Osterlind A.
Department of Dermato-Venereology, Bispebjerg Hospital, Copenhagen NV, Denmark.
OBJECTIVE--To determine the kinetics of azithromycin in cervical mucus and plasma. SUBJECTS AND METHODS--Azithromycin concentrations were determined in plasma and mucus samples from 20 women with cervical chlamydial infection one, seven and fourteen days after a single oral 1.0 g dose. RESULTS--In mucus, all measurable azithromycin concentrations were above the minimal inhibitory concentration against Chlamydia trachomatis on day 7 as well as on day 14. CONCLUSION--The high cervical mucus concentrations of azithromycin can explain the high clinical and microbiological efficacy.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7590717&dopt=Abstract
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J Antimicrob Chemother. 1995 May;35(5):623-9.
Azithromycin in an experimental Staphylococcus aureus abscess model.
Bamberger DM, Herndon BL, Suvarna PR.
Section of Infectious Diseases, University of Missouri-Kansas City School of Medicine 64108-2792, USA.
We studied the efficacy and pharmacokinetics of azithromycin in a rabbit tissue-cage Staphylococcus aureus abscess model. A dosage of 15 mg/kg/day azithromycin was administered to rabbits with 24 h or 2 week old infected tissue cages and to uninfected controls. Concentrations of azithromycin were higher in the infected compared with the uninfected tissue cages. Azithromycin was effective in reducing the bacterial concentrations in both groups of infected tissue cages by approximately 3 log10 cfu/mL compared with untreated controls after 8 days of therapy. Fifty percent of the 24 h and 29% of the 2 week infected tissue cages became culture-negative.
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J Clin Microbiol. 1995 May;33(5):1366-7.
Susceptibilities of 201 anaerobes to erythromycin, azithromycin, clarithromycin, and roxithromycin by oxyrase agar dilution and E test methodologies.
Spangler SK, Jacobs MR, Appelbaum PC.
Department of Pathology (Clinical Microbiology), Hershey Medical Center, Pennsylvania 17033, USA.
The susceptibility of 201 anaerobes to erythromycin, azithromycin, clarithromycin, and roxithromycin was tested by agar dilution and E test methods by using a commercially available plate and dish system (OxyDish) to provide anaerobic conditions. Plates were incubated for 48 h. MICs for 50% of strains tested and MICs for 90% of strains tested by agar dilution and E test methods corresponded within 1 doubling dilution for all compounds. When all antibiotics were considered together, agar and E test MICs were within 1 and 2 doubling dilutions of each other in 84 to 91% and > 99% of cases, respectively.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7615756&dopt=Abstract
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