Drugs online research references
Zhongguo Yao Li Xue Bao. 1993 May;14(3):197-200.
Effects of lisinopril and captopril on calcium in rat heart.
Wang JF, Xiao WB.
Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing, China.
We studied the effects of lisinopril (Lis) and captopril (Cap), two angiotensin-converting enzyme inhibitors, on calcium in ischemia/reperfusion and normal rat hearts. Ischemia/reperfusion hearts were subjected to 15 min ischemia followed by 1 or 30 min reperfusion. Lis 0.1 mumol.L-1 and Cap 200 mumol.L-1 decreased the concentration of calcium in ischemia/reperfusion hearts (the content of calcium in reperfusion 1 min heart were reduced from 4.0 +/- 0.6 to 2.7 +/- 0.5 and 3.0 +/- 0.9 mumol/g dry wt respectively). In cultured cell of neonatal rat heart, both drugs inhibited the uptake of 45Ca2+. The activity of Na+,K(+)-ATPase prepared from rat heart was increased (activity increased from 15.7 +/- 2.3 in control group to 21.2 +/- 2.0 and 22.0 +/- 3.1 mumol/h mg protein in Lis and Cap groups, respectively). This calcium lowering effects of Lis and Cap may be important in protecting the ischemia/reperfusion damage of myocardium.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8237390&dopt=Abstract
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Free Radic Res Commun. 1993;19(3):173-81.
Angiotensin converting enzyme inhibitors as oxygen free radical scavengers.
Mira ML, Silva MM, Queiroz MJ, Manso CF.
Instituto de Quimica Fisiologica, Faculdade de Medicina, Lisboa-Portugal.
The authors have compared the ability of two non-SH-containing angiotensin converting enzyme (ACE) inhibitors (enalaprilat and lisinopril) with an -SH containing ACE inhibitor (captopril) to scavenge the hydroxyl radical (.OH). All three compounds were able to scavenge .OH radicals generated in free solution at approximately diffusion-controlled rates (10(10) M-1 s-1) as established by the deoxyribose assay in the presence of EDTA. The compounds also inhibited deoxyribose degradation in reaction mixtures which did not contain EDTA but not so effectively. This later findings also suggests that they have some degree of metal-binding capability. Chemiluminescence assays of oxidation of hypoxanthine by xanthine oxidase in the presence of luminol, confirm that the three ACE inhibitors are oxygen free radical scavengers. Our results indicate that the presence of a sulphydryl group in the chemical structure of ACE inhibitors is not relevant for their oxygen free radical scavenging ability.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8244086&dopt=Abstract
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Pharm World Sci. 1993 Oct 15;15(5):219-24.
Decision analysis applied to the selection of angiotensin-converting enzyme inhibitors.
Santos Ramos B, Pina Vera MJ, Carvajal Gragera E, Atienza Fernandez M.
Servicio de Farmacia, Hospital Virgen del Rocio, Sevilla, Spain.
Decision analysis is applied to the group of angiotensin-converting enzyme inhibitors, in order to select those which should be included in the hospital formulary and to establish a research method which allows the reproduction of the process with new, related drugs. Captopril, enalapril and lisinopril were the alternatives considered. Evaluation criteria were efficacy, clinical experience, safety, dosage interval, hepatic bioactivation, interactions, dosage forms and cost. A relative weight was assigned through a survey among the hospital's staff. Each alternative was evaluated in relation to all criteria. Sensitivity analysis was applied to validate the method. Enalapril obtained the highest score, followed by lisinopril and captopril. The sensitivity analysis confirms this result. Enalapril is selected for the hospital formulary due to its higher score, although the differences between the three are very small.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8257959&dopt=Abstract
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