Drugs online research references
J Asthma. 1999 Dec;36(8):665-70.
Effects of angiotensin-converting enzyme (ACE) inhibitors on oxygen radical production and generation by murine lung alveolar macrophages.
Suzuki M, Teramoto S, Katayama H, Ohga E, Matsuse T, Ouchi Y.
Department of Geriatric Medicine, Tokyo University Hospital, Japan.
We examined the effect of angiotensin-converting enzyme (ACE) inhibitors on oxygen radical production before and generation after phorbol-myristate acetate (PMA) stimulation of lung alveolar macrophages. Lung free cells, predominantly pulmonary alveolar macrophages, were obtained from Fischer 344 rats and guinea pigs using bronchoalveolar lavage. The oxygen radicals produced by pulmonary alveolar macrophages with or without stimulation of PMA were measured by lucigenin-dependent chemiluminescence method using a photon counter, Lumat 9501 (Berthold, Germany). Alacepril, an ACE inhibitor with SH-group, inhibited the oxygen radical production and generation by lung alveolar macrophages harvested from both rats and guinea pigs in a dose-dependent fashion. Approximately 0.3 mM of alacepril inhibited 50% of oxygen radical production of lung alveolar macrophages in both rats and guinea pigs, whereas a higher concentration (1-5 mM) of lisinopril, an ACE inhibitor without SH-group, was necessary to inhibit 50% of oxygen radical production of lung alveolar macrophages in the animals. These results suggest that an ACE inhibitor with SH-group acts as an antioxidant in murine lungs and the treatment with the ACE inhibitor may reduce oxidant stress in hypertensive patients with asthma.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10609621&dopt=Abstract
word match zestril online literature
Am J Kidney Dis. 1988 Jun;11(6):499-507.
Effect of lisinopril monotherapy on renal hemodynamics.
Reams GP, Bauer JH.
Department of Medicine, University of Missouri School of Medicine, Columbia.
Nineteen essential hypertensive patients were entered into a protocol to assess the BP, humoral and renal effects of the angiotensin converting enzyme inhibitor, lisinopril (MK 521, 20 to 80 mg once daily), administered for 52 weeks. Specifically monitored prior to, and following 12 and 52 weeks of lisinopril monotherapy were plasma renin activity and plasma aldosterone, the clearances of creatinine, inulin and para-aminohippurate, and the 24-hour urinary excretion of protein. BP was well controlled. Plasma renin activity was stimulated, and plasma aldosterone was suppressed throughout the entire protocol. In contrast to the reported short-term and long-term renal effects of enalapril, lisinopril (a lysine analog of enalapril) had no short-term effect on renal function: glomerular filtration rate, effective renal plasma flow, filtration fraction (FF), renal vascular resistance (RVR), and protein excretion were all unchanged. However, following long-term therapy, both FF and RVR were decreased. Lisinopril appears to convey no specific renal pharmacological benefit.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2837083&dopt=Abstract
word match zestril online literature
Arch Int Pharmacodyn Ther. 1988 Mar-Apr;292:266-80.
Renal actions of the new angiotensin converting enzyme inhibitor CGS 16617.
Levens NR.
Research Department, Ciba-Geigy Corporation, Summit, NJ 07901.
Renal actions of the new angiotensin converting enzyme inhibitor CGS 16617 were evaluated in anesthetized dogs. Intravenous administration of 0.4 mg/kg CGS 16617 resulted in complete inhibition of the pressor response to 1 microgram angiotensin I (ANG I) for a 2 hr period. Over this period, i.v. injection of CGS 16617 significantly reduced mean arterial pressure (MAP) by 9 mmHg and significantly increased renal blood flow and glomerular filtration rate. Sodium and water excretion increased significantly following converting enzyme inhibition. Intravenous injection of CGS 16617 also markedly decreased urine osmolality and produced a highly significant increase in free water formation. Intravenous infusion of 0.5 microgram/kg per min saralasin also completely inhibited the pressor response produced by 1 microgram of ANG I. Except for the absence of a significant change in urinary osmolality, the changes in MAP and renal function produced by saralasin were essentially identical to those produced by CGS 16617. The results presented in this study demonstrate that the new converting enzyme inhibitor CGS 16617 has potent actions on renal function. The similarity of the changes in blood pressure and renal function produced by CGS 16617 to those of saralasin may suggest that the consequences of angiotensin converting enzyme inhibition in this model can largely be explained by inhibition of the renin-angiotensin system.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2840040&dopt=Abstract
word match zestril online literature
Herbs and Pharmaceuticals Online ||
Hair Million herbal formula for hair loss and hair growth ||
Antibiotics and prescription medications online literature ||