Drugs online research references
Clin Pharmacol Ther. 1997 Apr;61(4):476-87.
Comparative sexual side effects of bupropion, fluoxetine, paroxetine, and sertraline.
Modell JG, Katholi CR, Modell JD, DePalma RL.
Department of Psychiatry, University of Alabama at Birmingham School of Medicine 35294-0018, USA.
OBJECTIVE: To investigate patient reported prosexual side effects of the aminoketone antidepressant bupropion (INN, amfebutamone) and to compare directly the sexual side effects of bupropion and the selective serotonin reuptake inhibitor (SSRI) antidepressants fluoxetine, paroxetine, and sertraline. METHODS: One hundred seven psychiatric outpatient respondents receiving current treatment with one of the above antidepressants anonymously completed questionnaires that allowed reporting of both decreases and increases in sexual function. The main outcome measures were antidepressant-associated changes in libido, arousal, duration of time from arousal to orgasm, intensity of orgasm, and duration of orgasm relative to that experienced before the onset of the patients' psychiatric illnesses. RESULTS: Bupropion-treated patients reported significant increases in libido, level of arousal, intensity of orgasm, and duration of orgasm beyond levels experienced premorbidly. The three SSRIs to an equal degree significantly decreased libido, arousal, duration of orgasm, and intensity of orgasm below levels experienced premorbidly. Overall, 27% of the SSRI-treated patients had no adverse sexual side effects; in contrast, 86% of patients treated with bupropion had no adverse sexual effects, and 77% of bupropion-treated patients reported at least one aspect of heightened sexual functioning. CONCLUSIONS: SSRI-induced adverse sexual effects appear to be the rule rather than the exception and may be substantially underreported unless patients are specifically asked about the effects of these medications on various aspects of sexual function. In contrast, prosexual effects were reported by the majority of patients treated with bupropion. The findings are reviewed in light of the neurochemistry of these agents and the sexual response.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9129565&dopt=Abstract
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J Clin Psychiatry. 1983 May;44(5 Pt 2):163-9.
Bupropion's prophylactic efficacy in bipolar affective illness.
Shopsin B.
Three bipolar manic-depressive patients are described who, after responding to bupropion treatment for an acute depressive relapse, were maintained on the drug alone for a 1-year period, without recurrences of mania or depression. Discontinuation of medication was followed within 8 weeks by a manic or depressive recurrence in all three cases. Data are presented to suggest that bupropion probably exerted a prophylactic effect in preventing acute affective recurrences in these cases. This drug merits investigational attention as an alternative approach to current maintenance chemotherapy of recurrent affective disorder.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6406450&dopt=Abstract
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Gen Pharmacol. 1988;19(2):201-4.
Anorectic and behavioural effects of bupropion.
Zarrindast MR, Hosseini-Nia T.
Department of Pharmacology, Faculty of Medicine, University of Tehran, Iran.
1. Bupropion (12.5-75 mg kg-1) was given intraperitoneally to rats and was found to decrease the food consumption of the animals dose-dependently. While phenoxybenzamine, propranolol and methergoline failed to antagonize the anorectic effect of the drug; pimozide a dopamine receptor blocker decreased anorexia induced by bupropion. 2. Bupropion (12.5-50 mg kg-1) also caused a marked increase in locomotor activity of the rats. The increase in locomotion produced by bupropion was completely antagonized by pretreatment of the animals with pimozide and reserpine plus a-methyl-p-tyrosine, but not by pretreatment with phenoxybenzamine, propranolol or methergoline. 3. Taking into considerations the evidences of dopaminergic properties of bupropion shown by the others, it could be suggested that the anorexia and hyperactivity produced by bupropion may be induced through the indirect dopaminergic mechanism.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3127269&dopt=Abstract
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