Drugs online research references
Res Commun Chem Pathol Pharmacol. 1988 Feb;59(2):279-82.
The effect of H2-antagonists on the absorption of bupropion in rats.
al-Khamis KI, Kaka JS, Tanira MO.
Department of Clinical Pharmacy and Research Centre, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Bupropion absorption was investigated by oral administration of bupropion alone or in combination with cimetidine or ranitidine to rats. Blood samples were collected before and at 0.25, 0.5, 0.75, 1.0, 1.5, 2.0, 3.0, 4.5 and 6 h after bupropion administration. The assay of bupropion in plasma was carried out by an HPLC method. Cimetidine or ranitidine did not significantly affect the plasma bupropion concentrations on concurrent administration. No significant differences were observed between area under the curves (AUC)s, maximum plasma concentration, time to peak and the half-life of bupropion among the three groups. These results indicate that neither cimetidine nor ranitidine significantly affects the rate or the extent of bupropion absorption in rats.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2895943&dopt=Abstract
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Pharmacol Biochem Behav. 1986 Apr;24(4):795-9.
Effects of acute and chronic bupropion on locomotor activity and dopaminergic neurons.
Nielsen JA, Shannon NJ, Bero L, Moore KE.
Acute administration of bupropion (10 or 30 mg/kg) to rats increased locomotor activity in a dose-related manner. The highest dose increased the dopamine (DA) concentration while both doses reduced the concentration of dihydroxyphenylacetic acid (DOPAC) in the striatum. The enhancement of locomotor activity and the decrease of striatal DOPAC concentrations were increased with chronic administration (up to 40 days) of bupropion. The rate of DA synthesis in the striatum was increased by the acute administration of d-amphetamine but was not altered by acute or chronic administration of bupropion.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3086903&dopt=Abstract
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Brain Res. 1986 Jul 30;379(1):112-7.
Striatal dopamine uptake and swim performance of the aged rat.
Marshall JF, Altar CA.
The striatum and olfactory tubercle of 30-month-old F344 rats contain significantly (21-24%) less dopamine compared with young adult (8-month) animals. However, rats of the two age groups show identical Km and Vmax values for the kinetics of [3H]dopamine uptake into striatal homogenates; uptake into the olfactory tubercle also appeared unaffected in old age. The preservation of dopamine uptake despite reductions in content of the transmitter suggests that the forebrain dopaminergic nerve terminals are intact, but that reduced dopamine synthesis and/or enhanced degradation may occur in the existing terminals. Administration to senescent animals of the dopamine uptake blockers nomifensine or bupropion (but not the norepinephrine uptake blocker desmethylimipramine) improved their swim performance to levels comparable with young adult animals. The findings suggest that amine reuptake may limit the synaptic effectiveness of dopamine released in the aged striatum.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3091190&dopt=Abstract
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