Drugs online research references
Ann Neurol. 1985 Dec;18(6):692-7.
Acute effects of antidepressants on hippocampal seizures.
Clifford DB, Rutherford JL, Hicks FG, Zorumski CF.
Electrically kindled hippocampal seizures in rats were used to evaluate the acute effects of the antidepressants amitriptyline, imipramine, desipramine, bupropion, maprotiline, and trazodone on behavioral and electrical convulsions. All of the drugs reduced afterdischarge duration significantly. Behavioral seizures were not significantly reduced by bupropion or trazodone, whereas the other drugs did reduce seizure severity. Afterdischarge threshold was not modified by these drugs. In contrast, phenobarbital significantly elevated threshold and reduced seizure severity and afterdischarge duration. Amitriptyline was the most effective antidepressant, attenuating both seizure severity and afterdischarge duration.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3936402&dopt=Abstract
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Geriatrics. 2000 Dec;55(12):30-2, 35-9.
COPD. Interventions for smoking cessation and improved ventilatory function.
Petty TL.
University of Colorado Health Sciences Center, Denver, USA.
Chronic obstructive pulmonary disease (COPD) is a spectrum of smoking-related diseases that includes chronic bronchitis, emphysema, and asthmatic bronchitis. Smoking injures airways and alveoli, which invokes inflammatory processes in the respiratory tract that are mediated by oxidants, proteases, and inflammatory cytokines. Early identification of respiratory function loss and intervention are necessary to prevent progression to the disabling stages of COPD. Spirometry is a useful tool for assessing responses to smoking cessation and bronchoactive drugs. Anti-inflammatory drugs and antibiotics are useful to deal with exacerbations of bronchitis. Patient education and oxygen can improve the quality and duration of life in early and advanced stages of COPD.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11131852&dopt=Abstract
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Drug Metab Dispos. 2001 Feb;29(2):100-2.
Ritonavir, efavirenz, and nelfinavir inhibit CYP2B6 activity in vitro: potential drug interactions with bupropion.
Hesse LM, von Moltke LL, Shader RI, Greenblatt DJ.
Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, 136 Harrison Ave., Boston, Massachusetts, USA.
Since antiretroviral drugs are known to inhibit many cytochrome P450 isoforms, the inhibition of CYP2B6 by non-nucleoside reverse transcriptase inhibitors and viral protease inhibitors was studied in vitro in human liver microsomes using bupropion hydroxylation as the CYP2B6 index reaction. Mean IC(50) values (microM) for inhibition of bupropion hydroxylation were: nelfinavir (2.5), ritonavir (2.2), and efavirenz (5.5). The reaction was only weakly inhibited by indinavir, saquinavir, amprenavir, delavirdine, and nevirapine. The inhibition of bupropion hydroxylation in vitro by nelfinavir, ritonavir, and efavirenz indicates inhibitory potency versus CYP2B6 and suggests the potential for clinical drug interactions.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11159797&dopt=Abstract
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