Drugs online research references
Med Lett Drugs Ther. 1989 Oct 20;31(803):93-4.
Ovral as a "morning-after" contraceptive.
[No authors listed]
PIP: A brief review on how the combined oral contraceptive Ovral is used, without official US FDA approval, as a postcoital contraceptive is presented. The pill contains 50 mcg ethinyl estradiol and 0.5 mg norgestrel. Presumably the estrogen prevents implantation. The recommended dosage is 2 tablets taken 12 hours apart, preferably within 12-24 hours, and no later that 72 hours, after intercourse. Compared to a likelihood of pregnancy, in the event of unprotected intercourse, of 20% 3 days before ovulation, 25% 1 day before ovulation, and 15% on the day of ovulation, Ovral has been reported to prevent all by 1.8% of pregnancies. The highest failure rate cited was 7.4%. The only adverse effects noted were nausea, vomiting and breast tenderness. No fetal malformations have been published with this regimen.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2796842&dopt=Abstract
word match triphasil online literature
Akush Ginekol (Sofiia). 1989;28(3):63-6.
[Our experience in using the triphasic contraceptive trisiston for contraception]
[Article in Bulgarian]
Vasilev D, Katsarova M, Dikov I.
The authors carried out studies on 80 women, using Trisistone, a preparation of Germed, Jenapharm, DDR, in the course of 250 cycles, taking into consideration the advantages of triphasic contraceptive preparations as well as the fact that till this moment there were not applied in our country. A good contraceptive efficiency was established. No case with conception was recorded. The side effects were mild and and their frequency varies between 2.4 and 9.7% Irregular bleedings were the only disadvantage of Trisistone, which caused refusal for its usage. It is proposed that Trisistone should be used as an initial contraceptive preparation like the preparations with "mini" doses. In cases with good tolerance women should continue to use it, but they should take another contraceptive preparation, when bleeding occurs.
PIP: Contraceptive efficacy of triphasic combined preparation trisistone (East German drug identical to triphasil) was evaluated in 80 women with the average age of 31 years. The trisistone package consisted of 6 violet tablets (0.030 mg of ethinyl estradiol and 0.050 mg of 1- norgestrel), 6 pink tablets (0.40 mg of ethinyl estradiol and 0.075 mg of 1-norgestrel), and 9 orange tablets (0.030 mg of ethinyl estradiol and 0.125 mg of 1-norgestrel). The women started to take trisistone on day 1 of the menstrual cycle and continued to take tablets in exact sequence. Indications and contraindications for trisistone were similar to those for monophasic combined contraceptives. A total of 250 cycles were followed-up. Throughout the entire trial period, no women became pregnant. Mild side-effects included subjective sensation of pregnancy (9.7%), headache (7.1%), vertigo (2.4%), and weight gain (2.4%). Almost 20% of women developed hemorrhage, usually following administration of 8-9 tablets in the middle of the 2nd phase. Repeated hemorrhage during the 2nd and 3rd cycle was an indication for discontinuation of trisistone administration.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2802085&dopt=Abstract
word match triphasil online literature
Psychiatry Res. 1988 Jan;23(1):23-9.
Up-regulatory effect of triphasic oral contraceptive on platelet 3H-imipramine binding sites.
Weizman A, Morgenstern H, Kaplan B, Amiri Z, Tyano S, Ovadia Y, Rehavi M.
Geha Psychiatric Hospital, Belinson Medical Center, Tel-Aviv, Israel.
Triphasic oral contraceptive (Logynon) induced a significant increase (36%) in the maximal binding capacity of platelet membranes for [3H]imipramine. The increase was achieved in the second Logynon cycle as compared to pretreatment and first Logynon cycle binding values. The pill contains a combination of ethinyl estradiol and levonorgestrel, and it is as yet unclear which of the two hormones is responsible for the up-regulatory effect. The increase in the density of platelet imipramine binding sites may reflect a similar alteration in brain. The increase in imipramine binding did not correlate with alteration in mood as assessed by Beck Depression Inventory scores.
PIP: As an indicator of analogous brain serotonin metabolism, and by extension of depression tendency, platelet imipramine receptors were measured in women taking the triphasic oral contraceptive Logynon. Logynon (Schering AG Berlin/Bergkamen, Germany) contains levonorgestrel 50 mcg for 6 days, 75 mcg for 5 days and 125 mcg for 10 days, followed by 7 days pill-free; ethinyl estradiol doses are 30, 40 and 30 mcg for the same periods of time. The mean imipramine binding values (Bmax), calculated from Scatchard plots of tritiated uptake by platelets, was 429 in the control cycle, 396 on Day 14 of the 1st treatment cycle, and 582 in the 2nd treatment cycle (p0.02 vs pretreatment). Control means were 412 and 411. No significant differences were seen in affinity (Kd). There were no significant differences in mean Beck Depression Inventory tests, although 1 woman became clinically depressed, with BDI scores of 22 and 33 compared to 2 before taking Logynon. Her Bmax values were 626, 630 and 796 in the pretreatment, 1st and 2nd cycles respectively. Overall, the increase in imipramine binding did not correlate with Beck depression inventory scores.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2834763&dopt=Abstract
word match triphasil online literature
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