Drugs online research references
Am J Obstet Gynecol. 1989 May;160(5 Pt 2):1280-5.
From menarche to menopause: coronary artery atherosclerosis and protection in cynomolgus monkeys.
Clarkson TB, Adams MR, Kaplan JR, Shively CA, Koritnik DR.
Arteriosclerosis Research Center, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC 27103.
The effects on atherogenesis of stress, pregnancy, and oral contraceptive therapy were studied in a nonhuman primate model. The stress of social subordination was associated with ovarian dysfunction, unfavorable lipoprotein changes, and increased coronary artery atherosclerosis compared with nonstressed (socially dominant) or normal monkeys. Although pregnant animals exhibited lower high-density lipoprotein cholesterol concentrations, they had only one half as much diet-induced coronary artery atherosclerosis as their nonpregnant counterparts. Monkeys treated with an Ovral-like regimen also exhibited adverse lipoprotein changes. Nevertheless, prevalence and extent of coronary artery plaques decreased. We conclude that estrogen is an important factor in the animals' "female protection" against diet-induced atherosclerosis. We also suggest that the lowering of high-density lipoproteins by the progestin component of higher-dose contraceptives is not necessarily atherogenic if a sufficiently potent exogenous estrogen is administered concomitantly.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2719067&dopt=Abstract
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Acta Med Iugosl. 1989;43(2):113-20.
Serum testosterone response to low dose dexamethasone and combined contraceptive pill in subgroups of patients with polycystic ovary syndrome.
Prelevic G, Wurzburger M, Peric L.
Serum testosterone responses to the low dose dexamethasone and combined contraceptive pill were evaluated in a group of 42 patients with the polycystic ovary syndrome (PCOS) and in 10 normal-cycling women with idiopathic hirsutism. PCO patients were divided into subgroups according to their clinical presentation and hormonal characteristics. After the dexamethasone administration the serum testosterone levels remained significantly higher in all PCO patients compared to women with idiopathic hirsutism. Significant testosterone suppression was noticed in the subgroups with normal prolactin and normal LH levels (4.5 +/- 0.5 vs. 3.0 +/- 0.4 nmol/L, p less than 0.05 and 4.0 +/- 0.4 vs. 2.4 +/- 0.3 nmol/L, p less than 0.025 respectively), while it was not significant in any of the other subgroups studied. After a combined contraceptive pill administration a significant serum testosterone suppression was observed in all PCO subgroups (p less than 0.001), while it was not significant in women with idiopathic hirsutism. The results of this study show that ovaries are the main source of serum testosterone in PCO patients. This is particularly evident in patients with the highest LH/FSH ratio or hyperprolactinaemia.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2741713&dopt=Abstract
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Zentralbl Gynakol. 1989;111(12):793-9.
[The behavior of cytoplasmic progesterone receptors in the cycling endometrium and the effect of hormonal contraceptives]
[Article in German]
Carol W, Jager R, Martin P, Moller U.
Klinik fur Frauenheilkunde und Geburtshilfe, Bereichs Medizin, Friedrich-Schiller-Universitat Jena.
Concentration of cytosolic progesterone receptor (PR) was measured by means of an exchange procedure in the endometria of 80 women. Investigations carried out in 35 normal menstruating females showed a gradual increase of PR during the preovulatory and immediate postovulatory phases, decreasing to the lowest level at the end of the cycle. Measurements in endometrial samples obtained from women on combined hormonal contraceptives demonstrated a significant decline of PR concentration in the periovulatory phase resulting in a flattening of the sinusoid PR concentration curve. The stronger down regulation effect of the preparation containing 1.5 mg of dienogest is due to the higher progestogenic efficacy of dienogest in the respective dosage. We consider the down regulation phenomenon a useful means among others to characterize the progestogenic potency of a steroid.
PIP: Concentration of cytosolic progesterone receptor (PR) was measured by means of an exchange procedure in the endometria of 80 women. Investigation carried out on 35 normally menstruating females showed a gradual decrease of PR during the preovulatory and immediate postovulatory phases, decreasing to the lowest level at the end of the cycle. Measurements of endometrial samples obtained from women on combined hormonal contraceptives demonstrated a significant decline in PR concentration during the periovulatory phase which resulted in a flattening of the sinusoid PR concentration curve. The stronger "down regulation" effect of the preparation containing 1.5 mg of dienogest is due to the higher progestogenic efficacy of dienogest in its respective dosages. The authors consider this "down-regulation" phenomenon a useful means of characterizing the progestogenic potency of a steroid. (author's modified)
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2763749&dopt=Abstract
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