Drugs online research references
Int J Gynaecol Obstet. 1989 Oct;30(2):165-70.
A comparative study of Norinyl 1/35 versus Lo-Ovral in Ile-Ife Nigeria.
Ayangade O, Akinyemi A.
Department of Obstetrics, Gynecology & Perinatology, Faculty of Health Sciences, Obafemi Awolowo University, Ile-Ife, Nigeria.
A comparative analysis of those women on Norinyl 1/35 versus those on Lo-Ovral showed those on Norinyl 1/35 were significantly (P less than or equal to 0.05) older than women in the Lo-Ovral group. There were no significant differences (P greater than or equal to 0.05) between the groups for other characteristics at admission. There were no significant differences (P greater than or equal to 0.05) between the groups at follow-up in the number of women reporting serious complications, menstrual complaints or other pill-related problems. The continuation rates at 12 months were 79.4 for the Norinyl 1/35 group and 76.7 for the Lo-Ovral groups. There were no pregnancies reported during the study period.
PIP: A comparative study of 2 combined oral contraceptives was conducted on 100 women in Ile-Ife, Nigeria. Women were randomly allocated to receive either Lo-Ovral or Norinyl 1/35. Lo-Ovral and Norinyl 1/35 have similar low dose estrogen content, but different progestogen formulations and dosages. The women in the Lo-Ovral group were significantly younger than the Norinyl 1/35 group, with mean ages of 28.3 and 30.6 years respectively. There was no significant statistical difference between the education levels of the 2 groups. The mean parity of the groups was not statistically different, either. Only 3 women had serious complaints at the onset. 15 women, (31.9%) in Norinyl 1/35 and 9 (18.8%) in the Lo-Ovral group reported at least 1 menstrual complaint. However, the difference between the groups was not significant. 28 women (59.6%) in the Norinyl group, and 23 women (47%) in the Lo-Ovral group reported at least 1 complaint. All the women who had initial serious complaints chose to continue the method, and did not report the problems again at follow-up visits. Most of the other complaints decreased in most users with use. 10 women (21.2%) in the Norinyl group and 12 women (25.0%) in the Lo-Ovral group discontinued the method during the study. The difference was not statistically significant. Travel/movement was the primary reason for not continuing in both groups. The loss to follow-up rate was 33.3% and 27.1% for Norinyl and Lo-Ovral, respectively. No pregnancies were reported during the study. The dosages of estrogen used appear very effective and the progesterone component well tolerated. Gastrointestinal symptoms were minimal. Side effects did not contribute to the high rate of discontinuation.
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Ther Hung. 1989;37(3):168-71.
Therapeutic usefulness of anteovin.
Menyhart K.
The therapeutic effect of Anteovin has been examined in 86 women suffering from cycle disorder and menstrual complaints, respectively. The majority of women wanted to control conception at the same time, consequently the use of the tablet served double purpose. According to the results of examinations biphasic hormone therapy regulates successfully irregular cycles, the side-effects do not hinder therapy and the contraceptive effect of therapy is also reliable. These favourable properties support the opinion accepted increasingly that multiphasic tablets are the drugs of choice for both therapeutic and contraceptive purposes.
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Biomaterials. 1989 Nov;10(9):609-16.
Influence of steroid hormones on protein-platelet interaction at the blood-polymer interface.
Sharma CP, Chandy T.
Biosurface Technology Division, BMT Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Poojapura, Trivandrum, India.
To develop artificial materials for prolonged use in the vascular system, the complicated process of surface-induced thrombosis needs to be better understood. Steroidal hormones have a profound role in thrombosis and haemostasis, although adequate studies are not available to demonstrate their part in the thromboembolic phenomena that occur at the blood-foreign material interface. We studied the interfacial phenomena of five steroid hormonal drugs, Sustanon, Menstrogen, Mixogen, Durabolin and Ovral and their interaction with proteins and platelets toward an artificial surface using contact angle, polyacrylamide gel electrophoresis, trace labelling methods, etc. This study demonstrates the effect of these hormones to modulate platelet-surface attachment in the presence of platelet inducers. The addition of steroid hormones to the polymer-protein system can inhibit the level of surface-bound albumin where the fibrinogen binding to an artificial surface has been enhanced or unaltered. Steroids also increase platelet-surface attachment to variable degrees. Prolonged use of steroids or the oestrogen-containing oral contraceptive agents may not be advisable for patients having an artificial implant in contact with blood.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2611310&dopt=Abstract
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