Drugs online research references
Akush Ginekol (Mosk). 1989 Jul;(7):48-51.
[Changes in arterial blood pressure of women using hormonal contraceptives in relation to their cardiovascular history]
[Article in Russian]
Manuilova IA, Dubnitskaia LV, Korsakov SG.
The revealed correlation of blood pressure variation in the females who had used hormonal contraceptives and certain features of their cardiovascular histories were used to define the group of risk for borderline arterial hypertension during the intake of Ovidon or Non-Ovlon and to develop the criteria for differentiated choice of estrogen-gestagen drugs.
PIP: Potential adverse effects of estrogen-gestagen contraceptive agents on blood pressure were studied in 220 fertile women (19 to 45 years old) throughout 2152 menstrual cycles. The contraceptive agents used were ovidon, non-ovlon, rigevidon and triquilar. Blood pressure was measured prior to administration of contraceptive agents, after 3, 6, 9 and 12 months of administration, and 1 month after termination of administration of estrogen-gestagen contraceptives. Evaluation of the cardio-vascular status indicated that of 220 women 212 had various risk factors for elevated blood pressure: 28 had excessive body weight, 14 were older than 35 years, 21 had a history of complicated pregnancy and labor, 2 had neurocirculatory dystonia, 54 had family history of cardio- vascular diseases, 70 smoked at least 20 cigarettes; more than on half of women (163) complained of headache of various severity. Each risk factor was assigned a rank of 1 (weak), 2 (moderate), or 3 (strong). All contraceptive agents tested had an effect on blood pressure. The most pronounced elevation of blood pressure was observed after administration of ovidon: statistically significant increase of the systolic blood pressure was observed after 3-month administration and after 1 year this parameter exceeded the initial values by 6-7 mm Hg. During the use of non-ovlon, significant increase of the systolic blood pressure was first observed later, after 6 months, and 1 year later it exceeded the initial values only by 3-4 mm Hg. Significant increase of the diastolic pressure (by 3-6 mm Hg) was observed only after 9 months of ovidon administration and after 1 year of non-ovlon administration. Contraceptive agents with reduced dosage of steroid components (rigevidon or triquilar) produced less pronounced increase in systolic or diastolic blood pressure (less than by 2-3 mm Hg). The changes in blood pressure after the use of ovidon and non-ovlon were more pronounced in women with combined rank of risk factors of 7.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2478038&dopt=Abstract
word match triphasil online literature
Zh Mikrobiol Epidemiol Immunobiol. 2001 Jul-Aug;(4):100-4.
[Hormonal correction of the resident microflora of the vagina and uterus cervix in women with chronic cervicitis]
[Article in Russian]
Dolgushin II, Chernykh SL, Dolgushina VF.
State Medical Academy, Chelyabinsk, Russia.
Clinical, microbiological and hormonal examination of women with chronic cervicitis revealed lesions in the upper section of the reproductive tract in a high proportion of those examined, hormonal disturbances being registered in 96.7% of women. Dysbiotic manifestations (suppression of lacto- and bifidoflora and the excessive growth of opportunistic microorganisms) in the uterus cervix and vagina observed in patients with chronic cervititis were not associated with the etiology of the inflammatory process. The degree of dysmicrobiocenosis in the lower section of the genital tract in women with chronic cervicitis depends on the character of hormonal disturbances. The most significant inhibition of the resident flora was observed when ovarian dysfunction occurred and less significant--in cases of hyperprolactinemia and changes in the level of hypophysial hormones. Hormonal disturbances led to contamination of vagina and cervical canal with opportunistic microorganisms that was inversely proportional to the presence of lactic acid bacteria and bifidobacteria in these organs. Complex therapy of women with chronic cervicitis with the use of preparations for the correction of hormonal disturbances made it possible to restore the normal microflora of the genital tract and to improve the results of treatment.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11569243&dopt=Abstract
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Adv Contracept. 1989 Mar;5(1):1-11.
Pituitary-ovarian activity when switching from various monophasic pills to a triphasic pill.
Eyong E, Priddy AR, Killick SR, Elstein M.
Department of Obstetrics and Gynaecology, University Hospital of South Manchester, UK.
This study was prompted by the various recommendations given by different oral contraceptive manufacturers to women who wish to switch from a monophasic to a triphasic formulation. Ten women who switched from a variety of monophasic pills to a levonorgestrel triphasic pill formulation after a 7-day pill-free interval were studied. Follicular maturation was monitored by ultrasound scan, and the levels of serum follicle stimulating hormone (FSH), luteinizing hormone (LH), progesterone (P) and estradiol (E2) measured. Pituitary-ovarian activity was suppressed in six of the ten women studied, while in the remaining four women there was some pituitary-ovarian activity during the first 10 days on the triphasic pill. These findings suggest a shorter pill-free interval, as advised in USA data sheets, may be less likely to result in pill failures when women switch from a monophasic to a triphasic preparation.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2528892&dopt=Abstract
word match triphasil online literature
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