Drugs online research references
Zentralbl Gynakol. 1991;113(23):1298-303.
[Pharmacokinetics of contraceptive steroids with reference to long-term administration]
[Article in German]
Carol W, Klinger G, Michels W, Boer J, Pocha C.
Klinik fur Frauenheilkunde und Geburtshilfe, Friedrich-Schiller-Universitat Jena.
Pharmacokinetic investigations (c0h, c2h, c6h, c24h, AUC24) were carried out both in the first and last four days of a treatment cycle in patients of different ages, who used oral contraceptives at least for 12 months. 57 women took the preparation Trisiston (three-step-formulation with the components 0.03 mg ethinylestradiol (EE2) + 0.05 mg levonorgestrel (LNG), 0.04 mg EE2 + 0.075 mg LNG, 0.03 mg EE2 + 0.125 mg LNG), 23 subjects used Gravistat (0.05 mg EE2 + 0.125 mg LNG) and 17 patients were under Certostat, a preparation still in clinical evaluation (0.05 mg EE2 + 2.0 mg Dienogest (DNG)). The levels of EE2, LNG and DNG were measured by means of radioimmunoassays. Between the concentrations obtained after administration of a first and single tablet (earlier investigations) and those determined in long-time users during the first 4 days following the tablet-free interval no qualitative and quantitative differences were observed. Between the levels of EE2 and LNG determined in the first and last days of the treatment cycle, marked differences were found in patients under the formulations Trisiston and Gravistat, but not in those taking Certostat. It is concluded that a cyclic and reversible cumulating effect emerges under the influence of LNG-containing contraceptives, the mechanism of which cannot be explained solely by the increase of carrier protein capacity. It seems possibly due to an alteration of steroid metabolism resulting from the interaction between both components.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1796663&dopt=Abstract
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Biochem Int. 1991 Dec;25(5):973-84.
Effects of oral contraceptive pills on drug metabolizing enzymes and acid soluble sulfhydryl level in mouse liver.
Hussain SP, Chhabra SK, Rao AR.
Department of Carcinogenesis, Institut Suisse De Recherches Experimentales Sur Le Cancer, Lausanne.
The present paper reports the modulatory influence of two widely used combined oral contraceptive pills "OVRAL" and "NORACYCLINE" on hepatic phase I and II drug metabolizing enzymes and acid soluble sulfhydryl group of the mouse. Three different doses of the pills were used in this study i.e. D1 (1/2000th of a pill), D2 (1/200th of a pill) and D3 (1/20th of a pill). The sulfhydryl group increased significantly with the D1 and D2 dose of Ovral and the D2 dose of Noracycline. Dose D2 of both pills decreased cyt.P450 and cyt.b5 contents. D3 of Noracycline, however increased both the cytochrome levels. Dose D3 of Ovral and all three doses of Noracycline reduced the glutathione S-transferase activity.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1804114&dopt=Abstract
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Ther Hung. 1991;39(4):188-91.
Use of triphasic Tri-Regol tablet in women of borderline age.
Takacs G.
First Department of Obstetrics and Gynaecology, Semmelweis University Medical School, Budapest.
Tri-Regol, a triphasic oral contraceptive tablet, has been used by 52 young and premenopausal fertile women during 189 cycles. Pregnancy was not observed, complication did not occur, none of the women discontinued the treatment because of health reasons. The women of both borderline age groups tolerated the tablet well which even exerted a therapeutic effect by controlling partly puberal cycle anomalies, partly premenopausal complaints. According to the author's opinion Tri-Regol is a valuable contraceptive for borderline age groups and may be useful as hormone therapy in certain cases.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1811332&dopt=Abstract
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