Drugs online research references
Acta Med Hung. 1986;43(3):301-10.
Action of hormonal contraceptives on the coagulation system and some of its inhibitors.
Misz M, Beck P.
Changes in the level of inhibitors of the coagulation system, primarily of thrombin neutralizing factors have been studied during the prolonged use of four products of contraceptive preparations containing various amounts of oestrogens and progestogens, two fixed dose pills (Bisecurin, Ovidon), a low dose combination pill (Rigevidon) and a biphasic preparation (Anteovin). Thrombelastographic values referred to hypercoagulability while the results of other examinations indicating activation of the coagulation system did not show definite changes in comparison with the control. The activity and quantity of antithrombin III decreased but never below 80%. Except Anteovin all contraceptives significantly enhanced alpha 1-antitrypsin while alpha 2-macroglobulin levels, remained nearly the same as the control values. Attention is called to that the increased alpha 1-antitrypsin level may be a biochemical risk factor. The results showed that the increased coagulability and disposition to thromboembolic disorders caused by hormonal contraceptives may be attributed not only to the decrease of thrombin inhibitors but also to increased alpha 1-antitrypsin levels which may cause increased inhibition of the fibrinolytic system.
PIP: Inhibitors of the coagulation system were measured in 71 women taking 4 oral contraceptives for 1-8 years, 2 combined pills, Bisecurin and Ovidon, a low-dose combined pill, Rigevidon, and a biphasic, Anteovin. The article begins with a review of the clinical significance and recent research on serine protease inhibitors. The pill formulations were: Bisecurin, 50 mcg, ethinyl estradiol and 1 mg ethinodiol diacetate; Ovidon, 50 mcg, ethinyl estradiol and 250 mcg, d-norgestrel; Rigevidon, 30 mcg ethinyl estradiol and 150 mcg, d-norgestrel; Antiovin 50 mcg, ethinyl estradiol and 50 mcg, d-norgestrel for 11 days and with 125 mcg d-norgestrel for 10 days. Thromboelastographic values r and I, indicating hypercoagulation, were significantly higher for pill users compared to 28 controls. No change was seen in prothrombin time (PT), and partial prothrombin time (PTT), fibrinogen values or ethanol gelation. Antithrombin III biological activity and quantity assayed immunologically decreased as much as 20%. The fixed dose pills significantly enhanced alpha 1-antitrypsin, a possible biochemical risk factor for thromboembolic disease. Alpha 2-macroglobulin levels did not change. The results showed that the increased coagulability and enhanced incidence of thromboembolic disorders associated with oral contraception may be caused by a decrease in thrombin inhibitors as well as increased alpha 1 antitrypsin, which inhibits the fibrinolytic system.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2438639&dopt=Abstract
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Zentralbl Gynakol. 1988;110(4):241-5.
[Modification of serum lipids and glucose tolerance by sequential Ovosiston and Minisiston]
[Article in German]
Vesper VB, Feustel S.
Klinik und Poliklinik fur Gynakologie und Geburtshilfe, Bereichs Medizin (Charite) der Humboldt-Universitat.
The influence of two kinds of contraceptive pills, a sequential one and a combined one (Sequenz-Ovosiston and Minisiston), on serum lipoproteins and carbohydrate metabolism was investigated in 32 young patients who got these drugs for the first time during a period of 12 months. There were no pathological values of cholesterol, high density proteins, low density proteins, triglycerides or oral glucose tolerance test during and after the treatment. The authors summarized, that neither Sequenz-Ovosiston nor Minisiston increase the risk of atherosclerosis and of diabetes in young healthy women.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2453102&dopt=Abstract
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Zentralbl Gynakol. 1988;110(5):267-76.
[Morphologic changes in the epithelium of the uterine cervix in long-term administration of the 19-norsteroid-containing oral hormonal contraceptives Non-Ovlon and gravistat]
[Article in German]
Geissler U.
Klinik fur Gynakologie und Geburtshilfe, Medizinischen Akademie Carl Gustav Carus Dresden.
The objective of this study was to give a contribution to the question whether there are changes in the uterine cervix after longterm application of 19-norsteroid-containing contraceptives Non-Ovlon and Gravistat relating to carcinogenesis. Histologic examinations have been performed on 19,760 cervical sections obtained from 280 women aged 25-45 years. 141 women had taken Non-Ovlon or Gravistat for at least 5 years, 139 women had never taken hormonal contraceptives. The cervices were equally obtained from surgical- and conization material from 1976 to 1982. The evaluation was made according to 108 single characteristics of quality, semiquantity and topography. These characteristics were evaluated by electronic data processing. Our investigations revealed no morphological evidence for a relation between longterm application of Non-Ovlon or Gravistat and the occurrence of squamous epithelial or adenomatous cervical neoplasias.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2453979&dopt=Abstract
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