Drugs online research references
Skin Therapy Lett. 2001 Feb;6(5):1-3.
Oral contraceptives in the treatment of acne.
Tan JK, Degreef H.
Acne Research and Treatment Centre, Windsor, Ontario, Canada.
Oral contraceptives (OCs) can reduce acne by lowering the production of adrenal and ovarian androgens, by inhibiting 5-alpha-reductase, which in turn, reduces the levels of dihydrotestosterone, and by stimulating sex hormone binding globulin (SHBG), thus reducing the levels of free testosterone. In newer OCs, such as Tricyclen and Diane-35, the progestin component is minimally androgenic and anti-androgenic respectively, thereby enhancing the favorable profile of these products in the treatment of hyperandrogenic disorders, including acne. The efficacy of these agents and their long-term safety profile supports their use in various grades of acne in females: * As adjunctive therapy to topical agents for women with mild non-scarring acne desiring oral contraception * As primary therapy for patients with moderate non-scarring acne in combination with topical therapy and systemic antibiotics * As one of two preferred methods of contraception in patients with scarring and severe inflammatory acne being treated with systemic isotretinoin.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11242137&dopt=Abstract
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Ther Hung. 1992;40(1):16-9.
How rapid is the return of fertility after the use of Tri-Regol oral contraceptive?
Adam J.
Department of Obstetrics and Gynaecology, Schopf-Merei Agost Hospital, Budapest.
The study deals with the return of fertility following the discontinuance of the use of different oral contraceptives. On the basis of the evaluation of data of 222 cases the following were concluded: after the discontinuance of the use of oral contraceptives for a shorter-longer period delay may be observed in the return of fertility. This was not longer that 7 months in the evaluated cases. Compared to monophasic tablets, following the use of multiphasic tablets (Anteovin, Tri-Regol) regeneration, that is first ovulation and the following pregnancy, occur within a shorter period. The role of the duration of treatment in this delay could not be cleared because of the relatively low number of cases. Since, according to international data the post-pill return of fertility of nulliparas is slower than that of paras, the author highly recommends the use of multiphasic products for temporary contraception of nulliparas.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1585278&dopt=Abstract
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Clin Exp Obstet Gynecol. 1992;19(1):30-3.
The bone sparing effect of oral contraceptive use in non-smoking women.
Kitai E, Blum M, Kaplan B.
Neve Neeman Family Medical Clinic, Kupat Holim, Israel.
In a group of 30 women, mean age 23.7 years, we have examined the urinary calcium: creatinine ratio (Ca:Cr) as an indicator of bone resorption, before and 6.8 months after oral contraceptive (OC) use. Fasting Ca:Cr decreased significantly during OC use, being more pronounced in nonsmokers. We agree with those who propose the use of OC in women also after 35 years of age, in view of their good effect on bone density.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1606695&dopt=Abstract
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