Drugs online research references
Thromb Res. 1994 May 1;74(3):309-15.
The in vitro effect of aspirin on increased whole blood platelet aggregation in oral contraceptive users.
Norris LA, Bonnar J.
Trinity College Department of Obstetrics and Gynaecology, St. James's Hospital, Dublin, Ireland.
PIP: The effects of triphasic oral contraceptives on whole blood platelet aggregation in 36 Italian women are reported here. Aspirin's effects on platelet aggregation were also studied. 18 women took a triphasic oral contraceptive; 10 women took Trinordiol, while 8 took Trinovum for at least 90 days. The remaining 18 women took nothing and served as controls. The study was aligned with each woman's birth control pill cycle. Blood was taken daily on days 15-21 of their cycle. Either saline solution or acetylsalicylic acid was added to the blood samples and compared. All data was statistically analyzed using unpaired student's t-test. Effects of 3 aggregating agents, ADP, PAF, and EDTA, on platelet aggregation were studied. Arachidonic acid and adrenalin bitartrate were also studied in this manner. An increase in platelet aggregation was observed in women taking oral contraceptives. No difference was found between patients taking Trinordiol and those taking Trinovum. The results of this study indicate an increase in whole blood platelet sensitivity to collagen, adrenalin, and arachidonic acid when using oral contraceptives. Aspirin, at low doses, may have a role in preventing early thrombus formation in women taking oral contraceptives.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8042198&dopt=Abstract
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Akush Ginekol (Mosk). 1993;(3):26-30.
[The acceptability of current contraceptive methods to adolescents]
[Article in Russian]
Sotnikova EI, Dubnitskaia LV, Perminova SG.
The authors analyze the admissibility of present-day contraception methods in 107 adolescent girls who used oral anteovin and trisiston and in 128 ones who used copper-containing IUDs. Analysis has not revealed noticeable differences in the incidence of side effects in adolescents and a control group of women of a reproductive age. Spontaneous menses recovery occurred in all young patients within 26 to 36 days after the drugs were discontinued, and basal temperature biphasic pattern recovered in 70.2% of girls by the third month after IUD contraception discontinuation. Short courses (up to 6-12 months) of hormonal contraception are advisable for adolescents. IUD contraception complications presenting as expulsions and menstrual cycle disorders were 1.5-2 times more incident in the adolescents than in control women despite the preventive measures taken.
PIP: A total of 235 adolescents aged 15-20 years were investigated, of whom 107 (Group I) were using oral contraceptives (OCs) (Trisiston and Anteovin) and 128 (Group II) were using IUDs containing copper: Cu 7-mini, Medusa, and T Cu 200. In addition, 215 women aged 20-35 years were studied in two more groups: 115 were using the OCs Anteovin and Trikvilar (Group III) and 100 were using the IUDs T Cu 200, Cu 7-Standard, and Medusa 1, 2, and 3 (Group IV). The reliability of OCs proved to be complete without even one unplanned pregnancy, while there were 4 such cases in Group II and 3 cases in Group IV. Side effects affected 9.3% among women using OCs in Groups I and III compared to only 7.5% in women at the midpoint of reproductive age. Group I experienced dyspepsia, reduction of work performance, and change in libido, while Group III experienced mammary tension and intermenstrual bleeding. 94.4% of patients in Group I and 94.6% of women in Group III had a menstrual cycle of 28.1 +or- 0.6 days at the beginning of OC use; compared to 27-29 days after the first cycle under OC treatment. Premenstrual syndrome and oligomenorrhea were found in 46.7% of adolescents using OCs and 12.3% of adult OC users at the beginning of treatment; however, by the third month of use menstrual disorders disappeared in all patients, and premenstrual syndrome as well as mammary tension occurred 2-5 days before menstruation in only 2.6% of women in Group III. Among IUD users complications were reported in 9.4% of Group II and 6.3% of Group IV. The frequency of expulsion was around 1.2-2.2 (mean 1.53) per 100 women in the course of 1 year in the adolescent users and 0.67 in Group IV patients. After 4 months of IUD use 73% of adolescents and 80% of women in Group IV experienced bleeding, while IUD removal because of hyperpolymenorrhea had to be done in 1.2% of Group II and 0.7% of Group IV users.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8048682&dopt=Abstract
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Gynecol Endocrinol. 1993 Jun;7(2):123-8.
Does gonadotropin suppression result in follicular development in premature ovarian failure?
Buckler HM, Healy DL, Burger HG.
Prince Henry's Institute of Medical Research, Monash Medical Centre, Melbourne, Australia.
It was hypothesized that premature ovarian failure is a self-perpetuating problem and that suppression of the endogenously raised gonadotropin levels may allow synchronization of follicular growth, so that when the suppression is removed, follicular development may be stimulated by the rapid rise in follicle stimulating hormone (FSH) levels. Microgynon (ethinylestradiol, 30 micrograms and levonorgestrel, 150 micrograms) was administered to eight women with premature ovarian failure for 12 weeks. Serum samples were collected weekly for radioimmunoassay of FSH, luteinizing hormone (LH), estradiol, progesterone and inhibin. On stopping Microgynon, ovarian ultrasonography was carried out, in addition to blood sampling, to monitor any follicular growth. Both FSH and LH levels declined to the normal follicular-phase range after 5 weeks of Microgynon treatment (mean +/- SD: FSH, 6.5 +/- 1.2 IU/l; LH, 8.9 +/- 1.6 IU/l). Both hormone levels rose rapidly after stopping treatment and were above the normal follicular-phase range by the 1st week. FSH reached pretreatment levels by 3 weeks, but LH did not reach the previously high levels until 7 weeks after stopping Microgynon administration. Estradiol and immunoreactive inhibin levels in serum were undetectable throughout the study. No follicular growth was seen on ultrasound scanning. Therefore, gonadotropin suppression in premature ovarian failure does not result in a resumption of follicular activity.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8213226&dopt=Abstract
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