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Int J Vitam Nutr Res. 1980;50(1):29-34.
Effect of oral contraceptives on vitamin B6 nutriture of young women.

Vir SC, Love AH.

The effect of oral contraceptives (OC) on vitamin B6 status of young women was assessed by percentage stimulation of erythrocyte glutamic pyruvic transaminase (EGPT) activity. The subjects were studied under three groups--control (non OC users), cross-sectional study group (taking OC for over a period of 3 months) and follow up study group. No adverse effect of OC on mean basic EGPT, mean percentage stimulation level or in the incidence of deficiency was noted in cross-sectional study group as compared to controls. Similarly follow up of women before the initial of OC therapy and after a period of 3 months or 6 months usage also demonstrated no adverse effects on vitamin B6 nutriture. The vitamin B6 status showed no relationship with duration of OC use. Dietary vitamin B6 was below the recommended in majority of cases and showed no significant correlation with percentage stimulation of EGPT.

PIP: 3 groups of young women were studied to determine any effect oral contraceptives (OCs) may have on vitamin B6 status; this effect was assessed by percentage of stimulation of erythrocyte glutamic pyruvic transaminase (EGPT) activity. The 3 groups were: 1) control (non-OC users); 2) a cross-sectional study group who took OCs for 3 months; and 3) a follow-up study group. When the cross-sectional group was compared with controls, no adverse effect of OC use on mean EGPT, mean percent stimulation levels, or mean incidence of deficiency was found. Follow-up of the cross-sectional, using data from before OC use and at 3-6 months after use, similarly demonstrated no adverse effects on vitamin B6 nutrition. Therefore, it is concluded that vitamin B6 status shows no relationship with duration of OC use either. In the majority of cases, dietary vitamin B6 was below recommended levels, but this showed no significant correlation with percent stimulation of EGPT.

online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7390712&dopt=Abstract

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Acta Obstet Gynecol Scand. 1980;59(2):165-8.
Effect of estrogen/progestogen combinations on polymorphonuclear leucocyte chemotaxis.

Nilsson B, Damber MG, von Schoultz B.

The effects on leucocyte chemotaxis and on the mixed lymphocyte culture reaction were studied in fourteen women taking estrogen/progestogen combinations. An increase in leucocyte chemotaxis was found during hormonal treatment and sera from these women were found to inhibit the mixed lymphocyte culture reaction.

PIP: 14 women were studied before and after 2 months of treatment with estrogen/progestogen preparations to measure neutrophil chemotaxis during treatment and the effects of serum on control leukocytes and mixed lymphocyte reactions. Migration of neutrophils (chemotaxis) increased from 118.2+ or -7.4 microns to 137.9+ or -13.7 microns after hormonal treatment. This increase was highly significant (P .001). Control leukocytes showed no such migration. Significant depression of lymphocyte activity was found in cultures incubated with sera from women undergoing 2 months of hormone treatment. There was no difference between control and untreated cultures from the same women. In sum, leukocyte chemotaxis increased and mixed lymphocyte culture reaction was inhibited by combined regular or low-dose oral contraceptives.

online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7405554&dopt=Abstract

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Am J Clin Nutr. 1980 Sep;33(9):1940-5.
Effects of oral contraceptive agents on copper and zinc balance in young women.

Crews MG, Taper LJ, Ritchey SJ.

Young adult women were selected from a group of volunteers on the basis of present and past use of oral contraceptive agents. Subjects were either those who had never used oral contraceptives or those who had used an agent for a minimum of two menstrual cycles. All subjects were fed diets that provided 2.02 to 2.11 mg of copper and 9.15 to 9.10 mg of zinc daily in an 18-day controlled metabolic study. Both oral contraceptive users and nonusers were in negative zinc balance and zinc excretion as not different (P > 0.05) for the groups. Oral contraceptives did not alter (P > 0.05) the metabolic balance of copper; the mean copper retention values were -0.16 mg/day for the nonusers and -0.13 mg/day for the users of oral contraceptives. As anticipated from reports in the literature, the plasma copper levels were higher (P < 0.01) in the oral contraceptive group, but the levels of zinc were not different. Although blood levels of zinc and copper are usually changed with the use of oral contraceptives, the retention of the two nutrients appears not to be affected.

PIP: Young adult women were selected from a group of volunteers on the basis of present and past use of (OCs) oral contraceptives. Subjects were either those who had never used OCs or those who had used an agent for a minimum of 2 menstrual cycles. All subjects were fed diets which provided 2.02-2.11 mg of copper and 9.15-9.10 mg of zinc daily in an 18-day controlled metabolic study. Both OC users and nonusers were in negative zinc balance and zinc excretion was not different (P 0.05) for the groups. OCs did not alter the metabolic balance of copper (P 0.05); the mean copper retention values were -0.16 mg/day for the nonusers and -0.13 mg/day for OC users. As anticipated from reports in the literature, the plasma copper levels were higher (P 0.01) in the OC group, but the levels of zinc were not different. Although blood levels of zinc and copper are usually changed with the use of OCs, the retention of the 2 nutrients appears not to be affected.

online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7416062&dopt=Abstract

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