Drugs online research references
Akush Ginekol (Mosk). 1983 Nov;(11):14-7.
[Systemic changes during the use of hormonal contraceptives]
[Article in Russian]
Manuilova IA, Trutko NS, Dubnitskaia LV, Kuramshina AKh.
PIP: Systemic changes in the female were investigated before and during treatment with the combined oral contraceptives Ovidon and Rigevidon. The latter compound, with its estrogen/gestagen component reduced by 1/3 as compared to Ovidon, was shown to be less frequently associated with gastrointestinal disorders, headaches, weight changes, and produce smaller systemic changes. (author's modified)
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6666789&dopt=Abstract
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Akush Ginekol (Mosk). 1983 Nov;(11):19-22.
[Clinical data on the use of current oral contraceptives]
[Article in Russian]
Krymskaia ML, Khomasuridze AG.
PIP: The effectiveness and safety of 3 Hungarian 2nd and 3rd generation oral contraceptives (OCs) were studied. The study included 225 healthy women aged 18-40. 70 women were taking Ovidan, a 2nd generation combination OC that contains 50 mcg of ethinyl estradiol and 250 mcg of d-norgestrel. None of the women became pregnant in 562 menstrual cycles. Side effects were recorded in 32.8% of the cases, 37.4% with other combination OCs. 100 women were given Rigevidon--a 3rd generation combination OC with minimum doses of estrogenic and gestagenic components (30 mcg of ethinyl estradiol and 150 mcg of d-norgestrel). This preparation was 100% effective, while the occurrence of side effects (29%) was even lower than with Ovidan. 55 women took Postinor, a gestagenic postcoital OC containing .75 mg of d-norgestrel in each pill. The preparation was 100% effective. 20 women developed metrorrhagic hemorrhages; in 4 patients, menstrual delay was observed. Postinor, as a highly effective gestagenic agent, can also be used in the treatment of various gynecological disorders. Based on these results and the data available in the literature, wider application of Ovidan, Rigevidon, and Postinor for oral contraception and therapy is strongly recommended.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6666790&dopt=Abstract
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Rev Med Brux. 1984 Jan;5(1):13-9.
[Clinical study of the secondary effects associated with taking a triphasic anti-ovulatory contraceptive]
[Article in French]
Vekemans M.
PIP: 102 patients using Trinordiol, a triphasic oral contraceptive (OC) containing ethinyl estradiol and d-norgestrel, were followed for 932 cycles in a study of secondary effects. Follow-up visits were scheduled after 1,3, and 6 months and every 6 months thereafter. 26 patients discontinued use of the pills during the study after using them for a total of 159 cycles. 5 discontinued because of abdominal pain, 1 for breast tenderness, and 1 because of headaches or migraines. 7 discontinued because of metrorrhagia, 4 for weight gain, 3 for amenorrhea, 2 for nausea and vomiting, and 1 each for nervousness, water retention, acne, desire for pregnancy, leaving the country, hypertension, and unknown motivation. the average age of patients was 23.6 years, with a range from 14-48. 76% were aged 15-29 years. 52.9% were nulliparas. 58.8% were Belgian, 21.6% were from Mediterranean Europe, 10.8% were Moroccan, and 7.9% were from black Africa. Only 1 patient, a 37 year old, developed hypertension. 15 patients gained more than 2 kg and 17 lost more than 2 kg. 15.8% complained of spotting during the 1st cycle compared to 3.1% during the 6th cycle, 5.2% during cycle 7-12, and 9.1% during cycle 13-30. Among 35 patients who did not discontinue treatment, 7 complained of amenorrhea and 1 of scanty menstrual bleeding, 14 of pain including 7 cases of pelvic pain, 2 of dysmenorrhea, 3 of breast tenderness, and 2 of headaches, 15 of leukorrhea, 3 of nausea, 2 of dizziness, and 1 each of fatigue, acne, galactorrhea, and cutaneous pruritis. 1 case of myoma at the level of the uterine cornu was identified after 24 cycles of treatment. In all, 61 patients had some complaint, while 41 were totally satisfied. No patient became pregnant during the study.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6701404&dopt=Abstract
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