Drugs online research references
Zentralbl Gynakol. 1980;102(22):1273-82.
[Effects of hormonal contraceptives on parameters of lipid metabolism (author's transl)]
[Article in German]
Carol W, Klinger G.
Constant rise of triglycerides and low but regular increase of phospholipid concentrations in serum were observed as a consequence of intake of single-phase hormonal contraceptives. This has been paralleled by inconstant, moderate rise in cholesterol. Those effects are likely to demonstrate dependence on oestrogen amounts of the preparations in question as well as on both quality and quantity of the progestagenic component. Rising concentrations of low density lipoproteins were recordable with regularity. However, variegated results so far have been obtained from studies into the behaviour of high-density lipoproteins. -The mechanism of origin of those alterations, which usually did not surpass normal limits, and their relevance to clinical practice are discussed.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6164181&dopt=Abstract
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Cell Tissue Res. 1981;217(3):611-24.
Morphological and histochemical study of the endometrical effects of ovral in the baboon.
Dollar JR, Boots LR, Santolucito KA, Bagwell JN.
In an effort to better understand changes induced by hormonal contraceptives, a group of female baboons were administered Ovral for a period of 9 months. During this time the endometrium was sampled by transcervical uterine biopsy from both the treated animals and from a control group. The biopsies were all obtained between 10 and 14 days of the treatment cycle or the normal menstrual cycle. The endometrial glandular cells from the treated animals exhibited an accelerated maturation compared with the controls. Ultrastructurally this was reflected by increased cell size, numerous long, slender microvilli on the apical membranes, and increased development of the Golgi complex. Differences were also observed in the predominant type of granule seen in the apical cytoplasm. After 3 and 6 months of treatment with Ovral, no significant differences were noted between groups or between animals within a group. However, after 9 months of treatment, the endometrium displayed differences from the earlier experimental groups as well as individual variations. The functional correlates of these observations are discussed and compared to human endometrium.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6265093&dopt=Abstract
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Cancer. 2002 Apr 25;96(2):74-82.
Hormonal effects of Depo-Provera in cervical smears: a comparison with Triphasil and postmenopausal effects.
Kaptain S, Bloom LI, Weir MM.
Department of Pathology, St. Joseph's Wayne Hospital, Wayne, New Jersey, USA.
BACKGROUND: Long-acting injectable contraceptive agents may cause changes in cervical smears that could impair the detection of epithelial abnormalities. The objectives of the current study were to 1) compare the hormonal effects of depot-medroxyprogesterone acetate (Depo-Provera) (DP) in cervical smears with those of levonorgestrel and ethinyl estradiol (Triphasil) (TP) and postmenopausal (PM) changes; and 2) determine whether the duration of DP use affects squamous maturation. METHODS: Satisfactory cervical smears from 50 DP users, 55 TP users, and 51 PM patients were evaluated blindly for: 1) squamous cell curling, crowding, cytolysis, and navicular cell formation; 2) pseudoparakeratosis, blue blobs, and histiocytes; 3) endometrial cells and blood; 4) single or enlarged endocervical nuclei and mucin-depleted endocervical cells; 5) lactobacilli and coccobacilli amounts; and 6) squamous maturation (ratio of parabasal:intermediate:superficial cells). RESULTS: No statistically significant differences were observed for blue blobs, histiocytes, blood, endometrial cells, or single or enlarged endocervical nuclei among smears from the three groups. More smears from DP and TP users demonstrated squamous cell curling, crowding, and cytolysis as well as navicular cells and abundant lactobacilli compared with smears from PM patients. There were more PM smears with pseudoparakeratosis and mucin-depleted endocervical cells compared with the other groups. The majority of PM smears (98%) demonstrated predominantly parabasal cells with some intermediate cells. The majority of DP (86%) and TP (93%) smears demonstrated mostly intermediate and some superficial cells, regardless of the duration of DP use. CONCLUSIONS: Certain progestational-dependent effects (i.e., curling, crowding, navicular cells, and abundant lactobacilli) were identified more often in TP users compared with DP users and less often in PM patients. The mostly parabasal pattern observed in smears from PM patients contrasted with the predominantly intermediate pattern found in smears from DP and TP users. The duration of DP use did not appear to have any effect on squamous maturation. Copyright 2002 American Cancer Society.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11954024&dopt=Abstract
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