Drugs online research references
Contraception. 1986 May;33(5):463-71.
Suppression of ovarian function by Microgynon 30 in day 1 and day 5 "starters".
Taylor DR, Anthony FW, Dennis KJ.
The suppression of ovulation during the first treatment cycle with Microgynon 30 (150 micrograms levonorgestrel and 30 micrograms ethinyl oestradiol) for nine subjects starting the "pill" on day 1 of their cycle and five subjects on day 5 was investigated. Serum oestradiol and progesterone levels throughout the cycle and midcycle urinary LH levels were reliably suppressed in all day 1 "starters". Serum progesterone levels and urinary LH levels were also suppressed in day 5 "starters" but one subject produced oestradiol levels within the normal range of ovulatory cycles. Mean oestradiol levels of day 5 "starters" were found to be significantly higher than those of day 1 "starters" (p less than 0.05).
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3757512&dopt=Abstract
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Am J Obstet Gynecol. 1986 Oct;155(4):802-7.
Oral contraceptives and insulin receptor binding in normal women and those with previous gestational diabetes.
Skouby SO, Andersen O, Kuhl C.
The effect of a low-dose triphasic oral contraceptive (ethinyl estradiol and levonorgestrel) on glucose tolerance, plasma insulin response to a glucose challenge, and insulin receptor binding to monocytes and erythrocytes was investigated in seven women with previous gestational diabetes and seven nondiabetic control subjects. Investigations were performed in the luteal phase before the hormonal intake and after hormonal treatment for 2 and 6 months. Before treatment, women with previous gestational diabetes had significantly impaired glucose tolerance (p less than 0.05) when compared with the healthy controls, but no differences in insulin receptor binding were observed. Glucose tolerance and the insulin response to oral glucose remained unchanged in both groups during the treatment period. In the control subjects a significant decrease (p less than 0.05) in insulin receptor binding to monocytes was observed after hormonal intake for 6 months whereas the insulin receptor binding remained unchanged in the women with previous gestational diabetes. No correlation was found between the receptor binding data obtained from monocytes and erythrocytes in either group of women. The study demonstrates that in lean nondiabetic women and women with previous gestational diabetes of normal weight without first-degree history of diabetes there is no apparent direct association between glucose tolerance, plasma insulin levels, and insulin binding to erythrocytes and monocytes during intake of low-dose oral contraceptives.
PIP: The effect of a low-dose triphasic (ethinyl estradiol and levonorgestrel) on glucose tolerance, plasma insulin response to a glucose challenge, and insulin receptor binding to monocytes and erythrocytes was investigated in 7 women with previous gestational diabetes and 7 nondiabetic control subjects. Investigations were performed in the luteal before the hormonal intake and after hormonal treatment for 2 and 6 months. Before treatment, women with previous gestational diabetes had significantly impaired glucose tolerance (p0.05) when compared with the healthy controls, but no differences in insulin receptor were observed. Glucose tolerance and the insulin response to oral glucose remained unchanged in both groups during the treatment period. In the control subjects a significant decrease (p0.05) in insulin receptor binding to monocytes was observed after hormonal intake for 6 months whereas the insulin receptor binding remained unchanged in the women with previous gestational diabetes. No correlation was found between the receptor binding data obtained from monocytes and erythrocytes in either group of women. The study demonstrates that in lean nondiabetic women and women with previous gestational diabetes of normal weight without 1st-degree history of diabetes there is no apparent direct association between glucose tolerance, plasma insulin levels, and insulin binding to erythrocytes and monocytes during intake of low-dose oral contraceptives. author's modified
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3766633&dopt=Abstract
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Biomed Pharmacother. 1986;40(8):301-8.
Modified elimination of prednisolone in epileptic patients on carbamazepine monotherapy, and in women using low-dose oral contraceptives.
Olivesi A.
The pharmacokinetics of prednisolone in serum after prednisolone-21-phosphate intravenous infusion was compared in 8 chronic epileptic patients on carbamazepine monotherapy for 2 to 12 months, in 5 healthy females having used low-dose oral contraceptives (30-40 micrograms ethinylestradiol + 50-250 micrograms levonorgestrel) for 7 to 24 months, and in 9 other healthy subjects (5 females not using oral contraceptives, and 4 males). Elimination half-lives were shorter in the patients than in the 9 healthy subjects (1.98 +/- 0.48 versus 2.73 +/- 0.76 h, mean +/- SD, 0.02 less than p less than 0.05), and total clearances higher (4.20 +/- 0.53 versus 2.96 +/- 0.54 ml X min-1 X kg-1, p less than 0.02), while the volumes of distribution did not differ significantly. Among the healthy subjects, the oral contraceptive group exhibited a longer elimination half-life, and a lower total clearance, than each of the other two groups, who gave similar results (respectively 4.75 +/- 1.27, 3.05 +/- 0.75, and 2.33 +/- 0.66 h, p less than or equal to 0.05; 1.91 +/- 0.57, 2.95 +/- 0.60, and 2.97 +/- 0.57 ml X min-1 X kg-1, p less than or equal to 0.05); the volumes of distribution were not significantly different. These findings suggest that long-term treatments by carbamazepine and by these low-dose oral contraceptives may respectively increase and decrease the therapeutic requirements of prednisolone.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3814762&dopt=Abstract
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