Drugs online research references









East Afr Med J. 1987 Jul;64(7):442-7.
Changes in plasma HDL-cholesterol in women using oral contraceptives in Kenya.

Maina FW, Sekadde-Kigondu CB, Ojwang PJ, Mati JK.

PIP: 125 black Kenyan women attending the Kenyatta National Family Welfare Clinic were randomly allocated to combined and fixed dose oral contraceptives (Eugynon: 500 mcg dl-norgestrel + 50 mcg ethinyl estradiol or Microgynon: 150 mcg levonorgestel + 30 mcg ethinyl estradiol). They were between 18-33 years of age with a mean of 25 +or- 7 years. The mean parity of this group was 3 and they had a mean education standard of 8 years. Fasting blood sampled were taken on recruitment (control cycle) and thereafter once for cycles 1, 3, 6, 9, and 12 during OC use. HDL-cholesterol was estimated in the sear. The 2 OCs elicited a significant decrease in levels of HDL-cholesterol (p0.01). author's modified

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Clin Endocrinol (Oxf). 1986 Feb;24(2):127-33.
Effect of oral contraceptives on serum prolactin: a longitudinal study in 126 normal premenopausal women.

Hwang PL, Ng CS, Cheong ST.

A prospective longitudinal study was carried out in 126 normal premenopausal women aged 18-34 years to determine the effect of oral contraceptives containing less than 50 micrograms of oestrogen on serum prolactin concentration. The mean prolactin concentration in patients receiving oral contraceptives (n = 80) rose from a control level of 8.9 ng/ml to 10.2 ng/ml at 3 months (P less than 0.05) and 10.9 ng/ml at 12 months (P less than 0.001). In a parallel group of patients (n = 46) who used intrauterine devices for contraception, no significant change in serum prolactin concentration was observed over the same period. It is concluded that currently available oral contraceptives have a small but significant stimulatory effect on prolactin secretion in normal women.

online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3708872&dopt=Abstract

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Contraception. 1986 Apr;33(4):365-71.
The effect of vaginal administration of low-dose oral contraceptive tablets on human ovulation.

Souka AR, el Sokkary H, Kamel M, Hassan M.

The effect of vaginal administration of a low dose combined oral contraceptive pill containing 0.15 mg levonorgestrel and 0.03 mg ethinyl oestradiol was studied in twenty women for a total of 58 cycles. Ovulation was suppressed in all treatment cycles in women receiving two pills daily. Failure of suppression of ovulation occurred in four out of 26 treatment cycles in women receiving one pill daily. Only seven women complained of side effects; most of the side effects were mild and disappeared gradually within the first treatment cycle. Intermenstrual spotting was present in only one case receiving one pill daily. It is concluded that vaginal administration of low dose combined pills has a good ovulation suppression effect with minimal side effects and with good cycle control.

online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3731776&dopt=Abstract

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