Drugs online research references
Akush Ginekol (Mosk). 1988 Aug;(8):47-50.
[Acceptability of hormonal contraceptives with a low steroid content]
[Article in Russian]
Dubnitskaia LV.
PIP: Synthetic estrogen-gestagen preparations represent a practically 100% efficient birth control method that in addition have a regulating effect on the menstrual cycle, while lowering the frequency with which such diseases as PID. However, side effects due to the metabolic influence of the steroids limit their usage. During recent years, contraceptives with varying steroid contents, imitating the variations of the level of sex hormones in the blood during the menstrual cycle, so-called triphasic contraceptives, have been used. The article describes a comparative study of the efficiency and tolerance of two hormonal contraceptives, containing low doses of steroid components: monophasic Rigevidon and triphasic Triquilar. 110 healthy women aged 20-41 using these two contraceptives for a period of 3-12 months were observed. 14.5% using Rigevidon and 16.4% using Triquilar developed side-effects, e.g., coarsened mammary glands and gastrointestinal irregularities (with a frequency almost twice as high for Rigevidon users), headaches, and nausea. The side effects usually occurred during the first months of usage and then disappeared. Intermenstrual bleeding was observed 1.5 times less frequently for users of Rigevidon. No instances of arterial hypertension were reported. Planned pregnancies occurred for 14 of 15 patients within 6 months after discontinuation of the contraceptive. Spontaneous menstruation reoccurred during 26-35 days for all patients taking Rigevidon and for 96.5% of women using Triquilar. Triquilar shows less pronounced influence on the systolic and diastolic indicators than Rigevidon and the frequency of interrupted menstrual cycles during the first months of contraception was lower. High efficiency, low frequency of side effects, absence of clinically manifested complications reflect the high acceptability of the estrogen-gestagen-containing contraceptives, Rigevidon and Triquilar.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3195708&dopt=Abstract
word match triphasil online literature
Adv Contracept. 1988 Jun;4(2):143-9.
Influence of oral contraceptive treatment on blood pressure and 24-hour urinary catecholamine excretion in smoking as compared with non-smoking women.
Blum M, Zacharovich D, Gelernter I, Blum I.
Family Planning Clinic, Mishmar Hayarden, Kupat Holim Sick Fund, Israel.
Microgynon-30 was administered to 15 smoking (group B) and 14 non-smoking young women (group A) for a period of 4 months. Prior to the institution of treatment supine blood pressure and daily urinary catecholamine excretion (DUCE) were measured in both groups of patients. Both values were elevated in group B in comparison with group A. Treatment with Microgynon-30 for 4 months induced a significant increase in DUCE in both groups, the increase being most marked in group B (p less than 0.0004). The increased catecholamine excretion accompanied small non-significant elevations in blood pressure. It is concluded that treatment with low-dosage estrogen oral contraceptives produces a significant increase in daily catecholamine excretion, especially in patients who smoke.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3213672&dopt=Abstract
word match triphasil online literature
Acta Physiol Hung. 1988;72(3-4):355-8.
Relationship between central cholinergic and GABAergic neurotransmitters activity in the steroid treated rat.
Das PC, Dey CD, Pharikal K, Dasgupta S.
Department of Physiology, Calcutta University, College of Sciences and Technology, India.
Contraceptive steroid treatment to female rat alters the concentration of acetylcholine and gamma-aminobutyric acid, though not uniformly in most of the brain areas, i.e. in cerebellum, medulla oblongata-pons, hypothalamus, striatum-hippocampus, midbrain-thalamus-subthalamus, and cortex. Both neutrotransmitters vary conjointly in the hypothalamus and striatum-hippocampus after combined steroid treatment. This may indicate a concerted effect on the modulation of gonadotrophin release.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3250213&dopt=Abstract
word match triphasil online literature
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