Drugs online research references
Zentralbl Gynakol. 1987;109(8):521-6.
[Effect of the estrogen-progesterone combination preparations gravistat and Minisiston on carbohydrate metabolism]
[Article in German]
Albus C, Mannchen E.
The effect of the estrogen-progesteron-combinations Gravistat (0.05 mg ethynylestradiol and 0.125 mg levonorgestrel) on glucose tolerance and plasma insulin was studied before and after tree and twelve months of treatment. In each case ten young fertile women participated in this study with aged 19 to 34 years. The fasting blood glucose and the glucose tolerance did not differ significantly under Gravistat and Minisiston. Reversible changes in the carbohydrate tolerance are most pronounced during the adaptations phase. The plasma insulin levels was no changed statistically under Gravistat and Minisiston.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3111130&dopt=Abstract
word match triphasil online literature
Fertil Steril. 1988 Feb;49(2):349-55.
Effects of danazol, gonadotropin-releasing hormone agonist, and estrogen/progestogen combination on experimental endometriosis in the ovariectomized rat.
Henig I, Rawlins RG, Weinrib HP, Dmowski WP.
Department of Obstetrics and Gynecology, Rush Medical College, Chicago, Illinois 60612.
Direct effects of a gonadotropin-releasing hormone agonist (GnRHa), danazol, or estrogen/progestogen (E/P) on experimental endometriosis were evaluated in castrated female rats. Endometrial explants decreased in size following castration, but there was no further change in the treatment groups. Histologic examination indicated atrophy and regression of experimental endometriosis in all groups of castrated animals. As expected, following castration, serum estradiol (E2) became undetectable, serum progesterone (P4) decreased, and cytosolic E2 and P4 binding capacity in the endometrial explants was lower. However, in danazol-treated animals, serum P4 and E2 receptor concentrations were significantly higher than in all other castrated groups, and in both danazol and E/P treated animals, concentrations of P4 receptor were significantly higher than in castrated controls. In contrast, GnRHa treatment had no effect on serum E2 and P4 levels nor on E2 or P4 receptors. The authors conclude that danazol and E/P preparations may have a direct effect on the ectopic endometrium through interaction with steroid receptors.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3123280&dopt=Abstract
word match triphasil online literature
Contraception. 1988 Jul;38(1):19-26.
Lipid and lipoprotein changes during the seven days off oral contraception in women using two triphasic preparations.
Percival-Smith RK, Frohlich J, Jones WN, Abercrombie BA.
Student Health Service, University of British Columbia, Vancouver, Canada.
This study was designed to determine whether mean values for lipids and lipoproteins changed during the 21 days on oral contraceptive (OC) preparations and during the seven days off the pills. The design allowed for comparison of the effects of Triphasil and Ortho 777 and for examining the consistency over two pill cycles. The mean values for total cholesterol, HDL-cholesterol, LDL-cholesterol and HDL3-subfraction were consistently lower on Day 20 when compared to Day 2 (p less than 0.05) for the two cycles and higher on Day 2 of Cycle II when compared to Day 20 of Cycle I. This fall-rise-fall pattern was consistent for cholesterol in 17 out of 28 of the women studied and these women were heavier (p less than 0.05), had a greater mean Quetelet Index (p less than 0.05) and had been using OCs for a shorter mean period of time (p less than 0.05). Consistently higher apolipoprotein A1 mean values were found on Day 20 of both cycles for Triphasil users compared to Ortho 777 users (p less than 0.02). This paper discusses the importance of these findings in relation to study design when measuring for differences between OC preparations and changes over time.
PIP: This study was designed to determine whether mean values for lipids and lipoproteins changed during the 21 days on oral contraceptives (OCs) and during the 7 days off the pill. The design allowed for comparison of the effects of Triphasil and Ortho 777 and for examining the consistency over 2 pill cycles. The mean values for total cholesterol, HDL-cholesterol, LDL-cholesterol, and HDL3-subfraction were consistently lower on day 20 when compared to day 2 (P0.05) for the 2 cycles and higher on day 2 of cycle 2 when compared to day 20 of cycle 1. This fall-rise-fall pattern was consistent for cholesterol in 17 of 28 women studied and these women were heavier (P0.05), had a greater mean Quetelet Index (P0.05), and had been using OCs for a shorter mean period of time (P0.05). Consistently higher apolipoprotein Al mean values were found on day 20 of both cycles for Triphasil users compared to Ortho 777 users (P0.02). This paper discusses the importance of these findings in relation to study design when measuring for differences between OCs and changes over time. author's modified
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3168443&dopt=Abstract
word match triphasil online literature
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