Drugs online research references
J Endourol. 1997 Jun;11(3):207-9.
Neodymium:YAG laser coagulation prostatectomy for patients in urinary retention.
Kabalin JN.
Urology Section, Palo Alto VA Health Care System, CA, USA.
Urinary retention necessitating catheterization is the presenting complaint for a significant minority of men requiring surgical therapy for bladder outlet obstruction. A total of 67 men presented in acute or chronic urinary retention and underwent Nd:YAG laser prostatectomy. Their mean age was 71 years, the mean estimated excess transition zone tissue was 40 g, and the mean laser energy delivery was 48 kJ. The median postoperative catheterization time was 10 days. Five men required catheterization for > or = 6 weeks, and in five men, the catheter was removed within 48 hours. In four men (6%), a successful postoperative voiding trial was never achieved. Postoperatively, mean voiding measures for the remaining 63 men were a peak flow rate of 16.1 mL/sec, a post void residual volume of 113 mL, and an AUA Symptom Index score of 7.7. Complications included urinary tract infection in two, urethral stricture in one, and bladder neck contracture in 3 men. Four men have subsequently elected additional treatment for bladder outlet obstruction (two transurethral resections, one repeat laser, and one terazosin), for an overall treatment failure rate of 6 of 67 (9%), including the two men who remain catheterized. Laser coagulation prostatectomy produces little or no acute morbidity with a successful long-term voiding outcome in the majority of men requiring treatment for acute or chronic urinary retention.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9181452&dopt=Abstract
Mil Med. 1997 Jun;162(6):380-3.
Prostatodynia in United Nations peacekeeping forces in Haiti.
Drabick JJ, Gambel JM, Mackey JF.
Department of Bacterial Diseases, Walter Reed Army Institute of Research, Washington, DC 20307-5100, USA.
Prostatodynia is a clinical entity associated with voiding symptoms and pelvic pain suggestive of prostatitis but with a normal prostate examination and without evidence of inflammation or infection in expressed prostatic secretions. The problem tends to be chronic and is vexing in its management. Although thought to be a common condition, prevalence data are generally lacking. From June to October 1995, the U.S. Army's 86th Combat Support Hospital provided medical support to a multinational United Nations peacekeeping force in Haiti. Patients diagnosed with prostatodynia were more common (13 cases) than men with other urologic problems (urolithiasis, 6 cases; urinary tract infection, 6 cases; scrotal abscess/mass, 2 cases; epididymitis, 1 case). Patients tended to be young (mean age 29.8), had multiple visits, failed to respond to multiple courses of antibiotics for presumed "prostatitis," and denied recent sexual relations. Some patients reported having had similar symptoms on prolonged separation from their spouses in the past that resolved with resumption of normal intercourse. Masturbation, however, had no impact on symptoms and was painful in some individuals. Terazosin, an alpha-antagonist, and stress-reduction therapy led to improvement in some patients' symptoms. A discussion of these retrospective findings in light of what is known about the possible etiologies and treatment of prostatodynia is presented. Prostatodynia appears to be a common problem in deployed troops and can lead to frequent use of medical services. Physicians supporting long deployments need to be aware of this entity.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9183157&dopt=Abstract
Eur J Pharmacol. 1997 May 26;327(1):79-86.
[3H]R-terazosin binds selectively to alpha1-adrenoceptors over alpha2-adrenoceptors - comparison with racemic [3H]terazosin and [3H]prazosin.
Ireland LM, Cain JC, Rotert G, Thomas S, Shoghi S, Hancock AA, Kerwin JF Jr.
Abbott Laboratories, Department 4MN, Abbott Park, IL 60064-3500, USA.
Most tissue sources for adrenoceptors contain a mixed population of alpha1- and/or alpha2-adrenoceptor subtypes; thus studies using non-specific radioligands are complicated by receptor heterogeneity. The examination of alpha1-adrenoceptor radioligand binding by radiolabeled terazosin and its enantiomers was simplified by using mouse fibroblast cells, which are thymidine kinase mutant (LTK-), transfected with cloned alpha1a-, alpha1b-, and alpha1d-adrenoceptor subtypes. [3H]Terazosin and its enantiomers were equipotent at the alpha1b-adrenoceptor. [3H]R-Terazosin was significantly less potent than [3H]terazosin and [3H]S-terazosin at the alpha1a- and the alpha1d-adrenoceptors. Using tissue derived alpha-adrenoceptors prepared in cold 25 mM glycyl-glycine buffer, [3H]prazosin, [3H]terazosin and [3H]S-terazosin bound to two sites in the rat neonatal lung preparation consistent with the presence of both alpha1- and alpha2B-adrenoceptors. The relative binding potencies of these radioligands at these two sites correlated with low affinity binding to the alpha2B-adrenoceptor and high affinity binding to an alpha1-adrenoceptor. [3H]R-Terazosin, on the other hand, bound to a single site in the rat neonatal lung membrane preparation, most likely an alpha1-adrenoceptor. Thus, [3H]R-terazosin may be useful as a selective alpha1-adrenoceptor radioligand for establishing the functional role of adrenoceptors in tissues expressing multiple subtypes.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9185839&dopt=Abstract
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