Drugs online research references
Dig Dis Sci. 1995 Aug;40(8):1738-43.
Luminal dopamine modulates canine ileal water and electrolyte transport.
Barry MK, Maher MM, Gontarek JD, Jimenez RE, Yeo CJ.
Department of Surger, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.
Previous studies have suggested that dopamine stimulates active ileal ion absorption via alpha 2-adrenergic or dopaminergic receptor activation. Identification of a dopamine 1a receptor on rat enterocytes located in intestinal crypts prompted this investigation of the effect of luminally administered dopamine on water and ion transport in the canine ileum. Absorption studies (n = 27) were performed in dogs with 25-cm ileal Thiry-Vella fistulas. Perfusion with [14C] PEG was used to calculate absorption of water and electrolytes from the Thiry-Vella fistula. Experiments consisted of three 1-hr periods: basal, luminal drug infusion at 10(-4) M, and recovery. Agonists used included dopamine (DOP: alpha-adrenergic, D1 and D2 receptor) and SKF 38393 (D1 receptor). Antagonists used included terazosin (TZ: alpha 1) and yohimbine (YOH: alpha 2). DOP caused significant increases in water and electrolyte absorption. TZ and YOH prevented the dopamine-induced proabsorptive response. Luminal DOP may serve as a proabsorptive modulator of ileal transport, acting via alpha 1, alpha 2, and dopaminergic receptors. The development of more potent proabsorptive dopamine analogs, which maintain the ability to broadly activate mucosal receptors, may be useful in such clinical situations as diabetic diarrhea, short gut syndrome, or following small bowel transplantation.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7648973&dopt=Abstract
J Urol. 1993 Feb;149(2):395-9.
Medical management of benign prostatic hyperplasia: a canine model comparing the in vivo efficacy of alpha-1 adrenergic antagonists in the prostate.
Breslin D, Fields DW, Chou TC, Marion DN, Kane M, Vaughan ED Jr, Felsen D.
Department of Surgery/Division of Urology, New York Hospital-Cornell Medical Center, New York 10021.
Medical management of benign prostatic hyperplasia (BPH) is an alternative to surgical treatment of this disease. A major target for pharmacologic therapy is the alpha-1 adrenergic receptor, since activation of this receptor by endogenous catecholamines is thought to contribute to outlet obstruction. In the present study, we compared the potency of various alpha-1 adrenergic antagonists against epinephrine-induced contraction of the canine prostate. The drugs tested were dibenzyline, prazosin, terazosin and YM617. The rank order of potency, comparing inhibitory constants (Ki's), was found to be YM617 >> prazosin > terazosin > dibenzyline. This study is the first to compare all of these drugs directly in the prostate in vivo. The rank order of potency of the drugs is similar to the rank order of potency at other alpha-1 receptors. These results demonstrate that 1) our model is useful in confirming activity of drugs at the alpha-1 receptor and 2) the prostate alpha-1 receptor is similar to other alpha-1 receptors. Whether activity at the alpha-1 adrenergic receptor is a sufficient determinant of clinical efficacy of these drugs remains to be determined.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7678872&dopt=Abstract
Nippon Hinyokika Gakkai Zasshi. 1993 Apr;84(4):711-9.
[Alpha adrenergic mechanism on the reflex micturition in the male decerebrate dog]
[Article in Japanese]
Takahashi T.
Department of Urology, Akita University School of Medicine.
We investigated the alterations of urodynamic parameters of reflex micturition evoked by filling the bladder with physiological saline prior to and after the administration of midodrine (alpha 1 agonist), terazosin (alpha 1 antagonist), clonidine (alpha 2 agonist) and yohimbine (alpha 2 antagonist) in 28 male decerebrate dogs. The significant finding produced by midodrine was an increase in contraction pressure, while terazosin produced a significant decrease in threshold pressure, contraction pressure and urethral pressure. Clonidine produced a decrease in threshold pressure, urethral pressure and external urethral sphincter activity, while yohimbine produced a significant increase in bladder volume and urethral pressure. It seems that alpha 1 adrenergic activity modulates urethral closing pressure via postsynaptic alpha 1 receptors, and that alpha 2 adrenergic activity mainly modulates urethral closing pressure via presynaptic alpha 2 receptors in the lower urinary tract function.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7684100&dopt=Abstract
Herbs and Pharmaceuticals Online ||
Hair Million herbal formula for hair loss and hair growth ||
Wellstreet online pharmacy for click-order prescription medications ||
Altace Online Pharmacy ||
Rx Drugs USA, Prescription Drugs Online Pharmacy ||
Insurance plans and information ||
Insurance policies for all purposes ||
Antibiotics and prescription medications online literature ||