Drugs online research references
yeal.net
AIM: To establish new methods for the chiral separation and preparation of three new drugs, alfuzosin, terazosin and doxazosin. METHODS: By optimizing factors which affect the chiral separation, modifier of solvent, chiral additive, pH of mobile phase, modifier of organic base and stationary phase, the optimum condition for chiral separation were selected. The preparation of enantiomers was carried out on semi-preparative reverse phase column (7.8 mm x 250 mm C4 5 microns). Acetonitrile-water modified by the addition of carboxymethyl-beta-cyclodextrin (2%-5%, w/v) was applied as chiral mobile phase. RESULTS: The enantiomers of three new drugs were base-line-separated and milligram-scale samples of enantiomer were obtained. CONCLUSION: The newly established method can be used in research and development of the enantiomers of three new drugs.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12579804&dopt=Abstract
Urologiia. 2003 Jan-Feb;(1):15-7.
[Results of treatment of irritative symptoms and urinary retention in patients 1 year after radical retropubic prostatectomy]
[Article in Russian]
Veliev EI, Petrov SB.
AIM: To assess function of urinary retention and irritative symptoms from the lower urinary tracts in patients after radical prostatectomy for local prostatic cancer. MATERIAL AND METHODS: From November 1997 to May 2001 radical prostatectomy was performed in 181 patients. One year after the operation 86 patients with pT1c-T2b filled in the questionnaire on urinary retention (UR) and irritative symptoms. RESULTS: One year after radical prostatectomy complete UR was registered in 76% of the patients, partial UR in 20.5% and unsatisfactory UR in 3.5%. Uroflowmetrical and ultrasound investigations, urine seeding made possible to select 16 patients with irritative symptoms. 11 patients of this group received alpha-adrenoblocker terazosin with a good response. CONCLUSION: One year after radical prostatectomy UR (complete or partial) was observed in 96.5% patients. Irritative symptoms unrelated to stricture of vesicourethral anastomosis and inflammation can be climinated by administration of terazosin.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12621960&dopt=Abstract
J Pharm Biomed Anal. 2003 Mar 26;31(4):775-83.
The ICH guidance in practice: stress decomposition studies on three piperazinyl quinazoline adrenergic receptor-blocking agents and comparison of their degradation behaviour.
Ojha T, Bakshi M, Chakraborti AK, Singh S.
Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research, Sector 67, S.A.S. Nagar, Punjab 160062, India.
Stress degradation studies were carried out on three piperazinyl quinazoline alpha(1)-adrenergic receptor blockers, viz. prazosin, terazosin, and doxazosin, following the conditions prescribed in the parent drug stability testing guideline (Q1AR) issued by International Conference on Harmonization (ICH). All drugs showed significant decomposition at 80 degrees C in acidic conditions (0.1 M HCl) and complete degradation in alkaline conditions (0.1 M NaOH). Under both these conditions, 2-piperazinyl-6,7-dimethoxy-4-aminoquinazoline was formed as a major decomposition product in all three drugs. The degradation pattern under ICH-prescribed photolytic conditions in liquid and solid states was also similar for all the drugs. The light exposure resulted in the formation of a cluster of degradation products. No degradation was observed in neutral and oxidative conditions. In solid state, all drugs were stable at 50 degrees C in a 1-month study. In alkaline conditions, the order of sensitivity to degradation of the three drugs was doxazosin>terazosin>prazosin, while the same was terazosin>doxazosin>prazosin under acidic conditions. Mechanistic explanation is provided for the variable behaviour of decomposition.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12644204&dopt=Abstract
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