Tenuate online research references
Pharmacol Biochem Behav. 1976 Jan;4(1):45-51.
Self-administration of psychomotor stimulant drugs: the effects of unlimited access.
Johanson CE, Balster RL, Bonese K.
Rhesus monkeys surgically prepared with intravenous catheters were given 23 hr daily access to injection of either cocaine, d-amphetamine, 1-amphetamine, d-methamphetamine or diethylpropion on a fixed ratio 1 schedule of reinforcement for a maximum of 30 days. Responding was maintained by all these drugs but showed both day-to-day and hour-to-hour variability. The two animals self-administering 0.2 mg/kg/infusion cocaine died in less than 5 days. All 6 animals given access to 0.05 mg/kg/infusion d-amphetamine or 0.025 mg/kg/infusion d-methamphetamine also died, but tended to survive more days than animals exposed to cocaine. Three of the 5 animals whose responding was maintained by 0.5 mg/kg/infusion diethylpropion and one of the two animals whose responding was maintained by 0.05 mg/kg/infusion 1-amphetamine survived the entire 30 days despite high rates of intake. Food intake was initially decreased, but often returned to predrug levels and was not related to level of drug intake.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=4818&dopt=Abstract
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Behav Pharmacol. 1993 Dec;4(6):586-596.
Effects of pharmacological manipulations on "demand" for food by baboons.
Foltin RW.
The College of Physicians and Surgeons of Columbia University and the New York State Psychiatric Institute, 722 West 168th St, Unit 66, New York, NY 10032, USA.
In a study examining the effects of pharmacological manipulations on "demand" for food, responding of six adult male baboons (Papio c. anubis) was maintained under a fixed-ratio schedule of food reinforcement during daily 22h experimental sessions. Increasing the response requirement decreased daily food intake. Administration of anorectic drugs (amphetamine, fenfluramine, diethylpropion, phenmetrazine, phenylpropanolamine and mazindol) produced parallel dose-dependent downward shifts in responding at all response costs. In contrast, administration of the anxiolytic, diazepam, produced parallel dose-dependent upward shifts in responding at all response costs. Oral phencyclidine decreased intake during the first 8h of the session, but compensatory feeding later in the day eliminated this effect. Changes in pellet intake were fitted to a theoretical equation derived by Hursh et al. (1988) to describe changes in demand for a commodity. When responding increases as a result of increasing cost, demand is said to be inelastic, but when responding decreases as a result of increasing cost, demand is said to be elastic. Administration of anorectic drugs, while decreasing maximal intake at minimal cost, had no effect on the elasticity of demand for food. Similarly, diazepam increased maximal intake at minimal cost without affecting the elasticity of demand for food. The effect of anorectic drugs differs from the previously reported effects of caloric substitutes which increase the elasticity of demand for food. Thus, anorectic drugs do not function as caloric substitutes, in an economic sense, for food.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11224228&dopt=Abstract [PubMed - as supplied by publisher]
word search: diethylpropion tenuate online literature
Res Commun Chem Pathol Pharmacol. 1979 Oct;26(1):3-11.
The roles of brain noradrenaline and dopamine in the anorectic activity of diethylpropion in rats: a comparison with d-amphetamine.
Borsini F, Bendotti C, Carli M, Poggesi E, Samanin R.
The anorectic activity of diethylpropion and d-amphetamine was studied in rats subjected to various treatments known to affect brain monoamines. The effect of diethylpropion, like that of d-amphetamine, was completely prevented by a lesion of the ventral noradrenergic bundle, which selectively decreases brain noradrenaline, but was not significantly modified in desipramine pretreated rats by an intraventricular injection of 6-hydroxydopamine, a condition decreasing only dopamine. Pretreatment with penfluridol significantly reduced the effect of d-amphetamine but not that of diethylpropion. A non-significant reduction of drug effect was found with alpha-methyl-p-tyrosine. Lesion of the nucleus medianus raphe, which destroys central serotonin neurons, or treatment with methergoline, a central serotonin antagonist, caused no changes in the effects of both compounds. The findings show that integrity of central noradrenergic neurons is an important condition for diethylpropion and d-amphetamine to exert their anorectic effect. Dopamine does not seem to play any role in the effect of diethylpropion but might contribute to that of d-amphetamine. The data are against any involvement of brain serotonin in diethylpropion anorexia.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=515507&dopt=Abstract
word search: diethylpropion tenuate online literature
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