Tenuate online research references
Endocrinologie. 1987 Jul-Sep;25(3):179-86.
Decrease of urinary levels of adrenergic metabolites including conjugated MHPG after a short term course of diethylpropion in obese children fed a mixed, low-calorie diet.
Popa M, Stefanescu AM, Dumitriu L.
C. I. Parhon, Institute of Endocrinology, Bucharest, Romania.
A short term course (8-11 days) of diethylpropion 50 mg a day was administered to 12 obese children of both sexes fed a mixed low calorie diet containing about 1000 calories/day. A group of 10 obese children received the same diet and no medication. The sex-distribution was similar in both groups as well as the degree of overweight (appreciated by the Quettelet index). The urinary excretion of some noradrenergic derivative (adrenaline-A, noradrenaline-NA, vanillyl-mandelic acid VMA, metanephrines NM and methoxy hydroxyphenyl glycol-MHPG) and of homovanillic acid (HVA) was measured in both groups before and after drug therapy or diet, respectively. After the diethylpropion course, the urinary mean value of MHPG decreased (2.17 +/- 0.30, mean +/- SE vs 1.47 +/- 0.21) but the significance was borderline. The mean level excretion of NA, VMA, MN and HVA were significantly lower following diethylpropion. No significant change was observed in the diet-only group of patients as regards the same determinations. These observations are not entirely explained by the previous pharmacologic knowledge on diethylpropion and other sympathomimetic amines.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3685848&dopt=Abstract
word search: diethylpropion tenuate online literature
Pharmacol Biochem Behav. 1986 Oct;25(4):733-8.
Effect of mazindol, d-amphetamine and diethylpropion on purine nucleotide binding to brown adipose tissue.
Lupien JR, Bray GA.
Amphetamine, diethylpropion and mazindol were administered to rats in both acute and chronic experiments to measure the changes in purine nucleotide (GDP) binding to the mitochondria from interscapular brown adipose tissue. There was a dose-dependent response to acute treatment with mazindol, but no such effect with diethylpropion. The effects of mazindol and amphetamine were present as early as 3 hours after treatment, and persisted for at least 48 hours, when compared to vehicle-injected rats when all rats were fasted from the time of injection until study. There was no effect when these drugs were added in vitro to mitochondria from brown adipose tissue. Diethylpropion had no effect on GDP binding either in vivo or in vitro at any of the times tested. Following 11 days of treatment with diethylpropion, amphetamine or mazindol, there was a significant increase in purine nucleotide (GDP) binding to mitochondria only in the amphetamine-treated animals. There was no difference in body weight or food intake with any of the three drugs after the third day of chronic treatment. The differences between the effects of these three drugs and those of fenfluramine are discussed in terms of their different central mechanisms of action.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3786335&dopt=Abstract
word search: diethylpropion tenuate online literature
Physiol Behav. 1986;38(1):153-6.
Satiation restores brood care motivation in the female mouthbrooder Pseudocrenilabrus multicolor (Cichlidae).
Mrowka W.
The maternal mouthbrooder Pseudocrenilabrus multicolor takes up her eggs during spawning and carries them continuously in her mouth for 10-11 days at 27 degrees C. Then the young-by that time able to swim-are released from the mouth. The duration of mouthbrooding is controlled by an internal timing program in the mother [12]. In non-first-spawners brood care motivation (= readiness to take up brood into the mouth and keep it there) disappears within a few hours after brood removal. At the same time hunger-which is reduced to half of the normal level when brood care motivation is present-increases to the normal level [15]. In females without brood care motivation, satiation by food intake or by a water solution of 15 mg/l diethylpropion (an anorectic amphetamine-derivative), restores brood care motivation during a sensitive period of approximately 11 days after spawning. The point of release of adopted brood from the mouth depends on the duration of previous brood deprivation, but not on the state of brood care motivation nor on the hunger state during brood deprivation. The results suggest that above a certain level hunger inhibits brood care motivation. By contrast, the hunger state seems not to influence internal timing of mouthbrooding.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3786497&dopt=Abstract
word search: diethylpropion tenuate online literature
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