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Zhonghua Yi Xue Za Zhi (Taipei). 1991 Oct;48(4):305-9.
[The urinary screening and identification of amphetamines in clinical toxicology laboratory--VGH]

[Article in Chinese]

Lin WL, Deng JF, Chou LJ, Hung DZ, Tsai WJ.

Department of Medicine, Veterans General Hospital-Taipei.

Amphetamines abuse has recently become a problem in this country. Four case identification, we used Emit-d.a.u. amphetamine assay to screen the amphetamines in human urine, and then confirmed them by gas chromatography-ion trap detector (GC-ITD). From January 1989 to August 1990, 267 urinary samples were requested by the physicians for amphetamine identification. Six samples were accompanied with drug powders used by the patients. Among the 267 samples, 79 were confirmed for the presence for both of methamphetamine and amphetamine. Neither the presence of amphetamine nor methamphetamine itself was detected. Among the six packs of drug powder tested, methamphetamine but not amphetamine was detected in four. We found that fenfluramine and diethylpropion would have false positive amphetamine reactions in Emit-d.a.u. assay. All the samples originated from 34 hospitals were widely distributed in the country. Other drugs concomitantly used included ethanol, morphine, flunitrazepam and ephedrine. Since methamphetamine can be metabolized to amphetamine but not vers versa, our study confirmed the abuse of methamphetamine not amphetamine in this country.

online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1659927&dopt=Abstract

word search: diethylpropion tenuate online literature





Rapid Commun Mass Spectrom. 1991 Feb;5(2):59-61.
Mass spectrometric investigation of 2-aminopropiophenones and some of their metabolites.

Pokrajac M, Miljkovic B, Misailovic B.

Department of Pharmacology and Pharmacokinetics, Faculty of Pharmacy, University of Belgrade, Yugoslavia.

Complex metabolic mixtures of 2-aminopropiophenones, obtained both after in vitro and human in vivo metabolism of these compounds, have been investigated using both mass spectrometry and gas chromatography/mass spectrometry. The mass spectrometric fragmentation schemes of the compounds have been proposed and verified. The schemes are based on the characteristic fragments obtained by alpha-cleavage of these compounds using direct inlet mass spectrometry or gas chromatography/mass spectrometry. These findings were confirmed with chemical ionization mass spectrometry, when quasi-molecular (MH+) ions were obtained as the highest relative abundance ions for all the compounds investigated, and were used in metabolic investigations of 2-aminopropiophenones.

online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1804406&dopt=Abstract

word search: diethylpropion tenuate online literature














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