Tenuate online research references
Toxicol Appl Pharmacol. 2003 Jul 15;190(2):170-6.
Effects of diethylpropion treatment and withdrawal on aorta reactivity, endothelial factors and rat behavior.
Da Silva LB, Cordellini S.
Department of Pharmacology, Institute of Biosciences, University Estadual Paulista, Botucatu, Sao Paulo, Brazil.
Diethylpropion (DEP) is an amphetamine-like compound used as a coadjutant in the treatment of obesity and which presents toxicological importance as a drug of abuse. This drug causes important behavioral and cardiovascular complications; however, the vascular and behavioral alterations during DEP treatment and withdrawal, have not been determined. We evaluated the effects of DEP treatment and withdrawal on the rat aorta reactivity to noradrenaline, focusing on the endothelium, and the rat behavior during DEP treatment and withdrawal. DEP treatment caused a hyporreactivity to noradrenaline in aorta, reversible after 2 days of withdrawal and abolished by both the endothelium removal and the presence of L-NAME, but not by the presence of indomethacin. Furthermore, DEP treatment increased the general activity of rats. Contrarily, DEP withdrawal caused a decrease in the locomotor activity and an increase in grooming behavior, on the 2nd and 7th days after the interruption of the treatment, respectively. DEP treatment also caused an adaptive vascular response to noradrenaline that seems to be dependent on the increase in the endothelial nitric oxide system activity, but independent of prostaglandins synthesis. The data evidenced chronological differences in the adaptive responses of the vascular and central nervous systems induced by DEP treatment. Finally, a reversion of the adaptive response to DEP was observed in the vascular system during withdrawal, whereas a neuroadaptive process was still present in the central nervous system post-DEP. These findings advance on the understanding of the vascular and behavioral pathophysiological processes involved in the therapeutic and abusive uses of DEP.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12878046&dopt=Abstract
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Farmaco. 1992 May;47(5):649-60.
Studies on the compatibility of diethylpropion hydrochloride with carboxymethylcellulose and other dietary fibres.
Retuert PJ, Yazdani-Pedram M.
Departmento de Quimica, Facultad Ciencias Fis. Y Mat., Universidad de Chile, Santiago.
The combination of diethylpropion hydrochloride with carboxymethylcellulose induces decomposition of the drug. The principal decomposition products obtained were 1-phenyl-1,2-propanedione, benzoic acid and diethylamine as hydrochloride and benzoate salts. These phenomena have been explained with reference to basic decomposition scheme of the diethylpropion. Additionally, the behaviour of diethylpropion in mixtures with other dietary fibres such as methylcellulose, wheat bran and wheat germ was examined. Diethylpropion in combination with methylcellulose is rather stable while in mixtures with wheat bran and wheat germ suffers degradation. An increase in the weight of the excipient, probably due to chemical binding of the drug and other degradation products by the excipient, was observed in all these cases. The decomposition reactions were studied by applying a sequence of selective solvent extractions and using high-performance liquid chromatography (HPLC).
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1326976&dopt=Abstract
word search: diethylpropion tenuate online literature
Eisei Shikenjo Hokoku. 1992;(110):67-73.
[Studies on the identification of psychotropic substances. VIII. Preparation and various analytical data of reference standard of some stimulants, amfepramone, cathinone, N-ethylamphetamine, fenethylline, fenproporex and mefenorex]
[Article in Japanese]
Shimamine M, Takahashi K, Nakahara Y.
The Reference Standards for amfepramone, cathinone, N-ethylamphetamine, fenethylline, fenproporex and mefenorex were prepared. Their purities determined by HPLC were more than 99.5%. For the identification and determination of these six drugs, their analytical data were measured and discussed by TLC, UV, IR, HPLC, GC/MS and NMR.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1364439&dopt=Abstract
word search: diethylpropion tenuate online literature
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