Tenuate online research references
Physiologie. 1978 Apr-Jun;15(2):117-25.
Cardiovascular effects of amphepramone.
Safta L, Cuparencu B.
The i.v. administration of amphepramone in dogs induced a dose-related depressor reaction. This effect was due to a peripheral myotropic vasodilatation. When the drug was administered intracerebroventricularly it elicited a marked pressor response, due, to the release of catecholamines with its subsequent action on alpha-adrenergic receptors. Small doses of amphepramone administered in dogs, rats and rabbits, induced a sinus tachycardia. Larger doses brought about a sinus bradycardia, bradyarrhythmias, extrasystoles, ventricular bradycardia and ventricular fibrillation or asystolia. The respiratory movements as well as the EEG tracings were depressed by larger doses of amphepramone.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=97686&dopt=Abstract
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Proc West Pharmacol Soc. 1998;41:125-7.
The action of anfepramone on neurochemical and behavioral markers in rats.
Martinez M, Mercado O, Santamaria A, Galvan S, Vazquez M, Bucio V, Hall C, Hernandez R, Hurtazo A, Pego E, Rodriguez F, Salvatierra R, Sosa A, Rios C.
Departamento de Neuroquimica, Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez, Mexico, D.F., Mexico.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9836267&dopt=Abstract
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Arch Toxicol. 1998 Nov;72(11):738-43.
Chinese herbs nephropathy-associated slimming regimen induces tumours in the forestomach but no interstitial nephropathy in rats.
Cosyns JP, Goebbels RM, Liberton V, Schmeiser HH, Bieler CA, Bernard AM.
Department of Pathology, ANPS 1712 Catholic University of Louvain Medical School, Cliniques Universitaires St. Luc, Brussels, Belgium.
Chinese herbs nephropathy (CHN), a rapidly progressive interstitial fibrosis of the kidney, has been described in approximately 100 young Belgian women who had followed a slimming regimen containing some Chinese herbs. In 4 patients multifocal transitional cell carcinomas (TCC) were observed. Aristolochic acid (AA), suspected as the causal factor of CHN, is a well known carcinogen but its ability to induce fibrosis has never been demonstrated. The objective of this study was to evaluate the latter using doses of AA, durations of intoxication and delays of sacrifice known to yield tumours in rats. We also tested the hypothesis that a possible fibrogenic role of AA was enhanced by the other components of the slimming regimen. Male and female rats were treated orally with 10 mg isolated AA/kg per day for 5 days/week, or with approximately 0.15 mg AA/ kg per day 5 days/week contained in the herbal powder together with the other components prescribed in the slimming pills for 3 months. The animals were killed respectively 3 and 11 months later. At sacrifice, animals in both groups had developed the expected tumours but not fibrosis of the renal interstitium. Whether the fibrotic response observed in man is due to species and/or strain related differences in the response to AA or to other factors, remains to be determined. Interestingly, despite the addition of fenfluramine and diethylpropion, two drugs incriminated in the development of valvular heart disease, no cardiac abnormalities were observed.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9879812&dopt=Abstract
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