Tenuate online research references
Pharmacol Biochem Behav. 1995 May;51(1):89-96.
Conditioned place preferences, conditioned locomotion, and behavioral sensitization occur in rats treated with diethylpropion.
Reimer AR, Martin-Iverson MT, Urichuk LJ, Coutts RT, Byrne A.
Department of Psychiatry, University of Alberta, 1E7.44 W Mackenzie Health Sciences Centre, Edmonton, Canada.
Diethylpropion is a centrally acting appetite-suppressing drug thought to act primarily through catecholamine pathways in the brain. In the present study, four doses of diethylpropion (0, 10, 20, and 40 mg/kg, intraperitoneally) were administered to rats to examine the hypothesis that the drug has psychomotor stimulant properties such as the ability to induce conditioned behaviors and behavioural sensitization. The rats were administered drug and then vehicle on alternating days, and confined to a "drug" or vehicle-paired side of a two-compartment box for 16 pairings. Only the 10-mg/kg dose of diethylpropion increased spontaneous locomotor activity in comparison to vehicle; the 20- and 40-mg/kg doses significantly decreased spontaneous locomotion. All doses of diethylpropion decreased spontaneous rearing, and the 20-and 40-mg/kg doses produced significantly less rearing than the 10-mg/kg one. At the 10-mg/kg dose, conditioned place preferences, conditioned locomotion, and conditioned rearing were observed. The 40-mg/kg dose produced conditioned rearing and conditioned defecation. In response to a 5-mg/kg challenge injection of diethylpropion, behavioural sensitization in locomotion and rearing occurred in rats that had previously received any one of the three doses of diethylpropion. Over 36 days, decreased weight gain was observed only in the 20- and 40-mg/kg groups. The rats were killed 48 h after the last drug injection, and whole brain was analyzed for levels of the catecholamines, homovanillic acid (HVA), 3,4-dihydroxyphenylacetic acid (DOPAC), 5-HT (not a catecholamine), and 5-hydroxyindoleacetic acid (5-HIAA) by HPLC with electrochemical detection.(ABSTRACT TRUNCATED AT 250 WORDS)
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7617738&dopt=Abstract
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Rev Med Chil. 1993 Sep;121(9):1013-6.
[Diethylpropion in magisterial formulations. Influence of cellulosis derivatives on in vitro stability and availability]
[Article in Spanish]
Gomez M, Alvarez A, Cid E.
Facultad de Ciencias Quimicas y Farmaceuticas, Universidad de Chile, Santiago de Chile.
The aim of this work was to assess the degree of interaction between diethylpropion and some cellulosic derivatives widely used in anorexigenic prescriptions. Our in vitro results show that sodium carboxymethylcellulose and methylcellulose cause a significant degradation of diethylpropion, the first having a greater effect. Dissolution essays showed that the availability of the drug is vastly reduced by cellulosic derivatives. Provided the close relation between the dissolution and absorption characteristics of a drug, it is possible to predict that this association will result in a poor bioavailability.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8191150&dopt=Abstract
word search: diethylpropion tenuate online literature
Psychopharmacology (Berl). 1976 Nov 10;50(2):165-9.
Experimental observations on the effect of amphepramone on the behavior, locomotion, pentretrazol seizures and electroencephalogram.
Safta L, Cuparencu B, Sirbu A, Secareanu A.
Amphepramone, an anorectic agent, has been found to possess stimulant properties on the C.N.S. in animals, producing hypermotility and stereotyped movements which can be antagonized with neuroleptics. The stimulant activity of amphepramone observed in animals can be correlated with the amphetamine like psychosis observed in humans.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=826957&dopt=Abstract
word search: diethylpropion tenuate online literature
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