Tenuate online research references
Int J Vitam Nutr Res. 1981;51(3):247-53.
Anorectic drugs and vitamin C: role in appetite and brain ascorbic acid in guineapigs.
Odumosu A.
The role of daily administration of anorectic drugs (fenfluramine, mazindol and diethylpropion) with or without Vitamin C supplement, in the appetite and brain ascorbic acid, had been investigated in guineapigs receiving a daily Vitamin C-deficient diet for 24 days. Food intake was reduced by diethylpropion in the scorbutic male and female guineapigs but to a smaller extent by fenfluramine or mazindol. Supplementary Vitamin C daily significantly inhibited the anorectic actions of these drugs. In relation to the brain ascorbic acid level in the scorbutic gunieapigs, the initial stable level of brain ascorbic acid was significantly reduced by fenfluramine in both sexes by day 24, (P less than 0.05). Both mazindol and diethylpropion did not cause such reductions in the initial brain ascorbic acid. The three anorectic drugs prevented the rise in brain ascorbic acid normally associated with supplementary Vitamin C. It appears that brain ascorbic acid level can make metabolic readjustment during anorexia caused by diethylpropion and mazindol but not that caused by fenfluramine in guineapigs.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7319724&dopt=Abstract
word search: diethylpropion tenuate online literature
J Pharm Sci. 1975 Jun;64(6):1041-3.
GLC determination of phendimetrazine in serum.
Hundt HK, Clark EC, Muller FO.
A sensitive, specific, and quantitative GLC method for the determination of phendimetrazine in serum is described. The procedure involves the addition of an internal standard to serum samples, followed by extraction at pH 13 into toluene. The extracted bases are back-extracted into 1 ml of 4 M hydrochloric acid and again into 100 mu1 of chloroform after making the 4 M hydrochloric acid extract basic with 1.5 ml of 4 M sodium hydroxide. The sensitivity of the method is such that 25 ng of material can be detected in 5 ml of serum.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1173373&dopt=Abstract
word search: diethylpropion tenuate online literature
Acta Vitaminol Enzymol. 1981;3(2):96-102.
Vitamin C and weight reducing drugs on brain ascorbic acid in guinea pigs.
Odumosu A.
A comparison has been made of the effects of d(+) fenfluramine, Mazindol and Diethylpropion on the changes in body weight and brain ascorbic acid concentrations in male and female guinea pigs receiving vitamin C-deficient diet daily with or without daily supplementary vitamin C for 24 days. Bodyweight increases initially; the subsequent decrease was more rapid in scorbutic male than in the female guinea pigs. The weight-reducing drugs prevented the initial rise in weight of these ascorbutic guinea pigs. Fenfluramine caused the greatest fall in weight in both sexes, the effect being more pronounced in the males. Supplementary vitamin C reduced the anti-obesity actions of fenfluramine, Mazindol and Diethylpropion. Brain ascorbic acid level in scorbutic guinea pigs was more significantly reduced by fenfluramine than by either Mazindol or Diethylpropion after 24 days administration. These drugs prevented the rise in brain ascorbic acid normally produced by supplementary vitamin C. The reduction brain ascorbic acid appears to be related to the loss of weight more in the males than in the females.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7325103&dopt=Abstract
word search: diethylpropion tenuate online literature
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