Tenuate online research references
Pharmacol Biochem Behav. 1981 Jun;14(6):799-804.
Effects of anorectic drugs and prior feeding on food-rewarded runway behavior.
Thurlby PL, Samanin R.
Two treatments that act through central catecholamine pathways and are normally found to be strongly anorectic (d-amphetamine, 1.25 mg/kg and diethylpropion, 5.00 mg/kg) failed to influence either latency to run or running velocity in single trial running for food reward. In contrast, d-fenfluramine (2.5 mg/kg), which normally has similar anorectic potency but acts via a serotoninergic mechanism, significantly increased latency and decreased running velocity. Prior feeding (30 min ad lib access to food) also decreased runway performance to a similar degree. Further studies, using a 3 trial procedure where rats were allowed to feed for 30 sec following each run, revealed that d-amphetamine (1.25 mg/kg), both with and without penfluridol pretreatment (2.5 mg/kg), failed to affect running velocity or the amount of food eaten. However, d-fenfluramine (2.5 mg/kg) and a postsynaptic serotonin receptor agonist, m-chlorophenylpiperazne (1.0, 2.0 mg/kg) led to a significant reduction in these measurements. Thus it appears that "serotoninergic" anorectic drugs, like the state induced by prefeeding, depress food-rewarded runway behavior whereas "catecholaminergic" anorectic agents lack such effect.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7255515&dopt=Abstract
word search: diethylpropion tenuate online literature
Pharmacol Biochem Behav. 1981 Aug;15(2):303-10.
(--)-threo-Chlorocitric acid: a novel anorectic agent.
Sullivan AC, Dairman W, Triscari J.
A new class of peripherally acting anorectics is described in these studies. The four stereoisomers of chlorocitric acid which are structurally similar to the known anorectic, (--)-threo-hydroxycitric acid, all suppressed food intake when administered at high doses to rats. Only one of these isomers, (--)-threo-chlorocitric acid, retained its anorectic activity at lower doses. The anorectic potency of (--)-threo-chlorocitric acid was approximately 40-fold greater in dogs than in lean and obese rats. The decreased food intake in rats resulted in a significant reduction of body lipid, without affecting protein levels. In contrast to the tolerance which was observed with the continued administration of mazindol or diethylpropion, tolerance to the anorectic effect of (--)-threo-chlorocitric acid did not develop. These studies suggest that (--)-threo-chlorocitric acid might be useful as an antiobesity agent.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7312900&dopt=Abstract
word search: diethylpropion tenuate online literature
word search: diethylpropion tenuate online literature
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