Tenuate online research references
Int J Obes. 1983;7(3):195-9.
Lowering of serum total T3 during a conventional slimming regime.
Stokholm KH, Hansen MS.
Serum concentrations of total triiodothyronine (T3) and thyroxine (T4) were determined in 28 obese out-patients before and after 12 weeks of treatment with a conventional slimming diet of 5.2 MJ (1245 kcal). Twenty-one of the patients were also given central stimulating anorectics (diethylpropion and 'Elsinore-pill' containing ephedrine). The median weight loss was 8.1 kg (range 0.4-19.1 kg). After the treatment a small, but significant (P less than 0.02), fall in serum T3 could be demonstrated whilst serum T4 was unaffected. The median fall in T3 in percentage of pretreatment value was 9 per cent (96 per cent confidence limits: 4-16 per cent). Neither serum T3 nor serum T4 correlated with the initial body weight, overweight or energy intake. In the patients treated with anorectics serum T4 was not elevated after 12 weeks, indicating that a possible sympatomimetic effect of central stimulating anorectics upon the thyroid gland is only temporary.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6885228&dopt=Abstract
word search: diethylpropion tenuate online literature
Life Sci. 1983 Sep 26;33(13):1269-75.
Anorectic drugs which stimulate thermogenesis.
Lang SS, Danforth E Jr, Lien EL.
Two anorectic drugs commonly prescribed as adjuncts in weight control and a third experimental drug were studied in rats for their anorectic and possible thermogenic activities. Diethylpropion, a congener of amphetamine, mazindol, which is chemically unrelated to amphetamine, and ciclazindol, an experimental drug structurally similar to mazindol, were given in graded doses to determine their effect on food and oxygen consumption (VO2). Anorectic effects exhibited by diethylpropion and mazindol were similar and more potent than ciclazindol. Both resting and anesthetized VO2 measurements were done to assess the thermogenic activity of the drugs. Anesthetized VO2 was performed in an attempt to separate peripheral from centrally-mediated actions of the drugs. Amphetamine was also tested at 1.0 mg/kg in order to correlate relative potencies. Mazindol, but not diethylpropion or ciclazindol, produced a dose response increase in resting VO2. At the 1.0 mg/kg dose, amphetamine produced a greater increase in resting VO2 than mazindol. At this dose, both drugs elicited centrally-induced alertness, although amphetamine elicited greater activity than mazindol. Mazindol and diethylpropion, but not ciclazindol, caused a dose-related increase in anesthetized VO2. The anesthetized VO2 response to amphetamine at 1 mg/kg was greater than the responses of mazindol and diethylpropion at 3.0 mg/kg. These findings confirm the previously recognized anorectic effects of mazindol and diethylpropion and also demonstrate that mazindol and diethylpropion but not ciclazindol (at the doses used) produced dose-related increases in VO2 (energy expenditure) by stimulating directly peripheral mechanisms and in the case of mazindol central mechanisms as well.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6888178&dopt=Abstract
word search: diethylpropion tenuate online literature
word search: diethylpropion tenuate online literature
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