Drugs online research references
Yao Xue Xue Bao. 1990;25(6):451-6.
[Construction and application of atropine flow-through sensor in flow injection analysis]
[Article in Chinese]
Liu WZ, Wu PZ, Yan Z, Yang CH, Li AJ, Xu RZ.
Hubei Provincial Institute for Drug Control, Wuhan.
A new kind of flow-through sensor for atropine has been studied. It exhibits Nernstian response for atropine with a slope of 54 +/- 1 mV/decade over the concentration range of 0.02-200 mmol/L at pH 5-8. The sensitivity coefficients of common compounds were determined. Only bromo-geramine, clonidine, strychnine and amantadine showed remarkable interference. Direct potentiometry for determination of atropine showed an average recovery of 99.2% and a relative standard deviation of 1.3%. It has been used in flow injection analysis (FIA) of atropine, anisodamine and scopolamine and belladonna preparations. Rate of analysis of as high as 60-100 samples/h was achieved.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2284973&dopt=Abstract
J Pharmacol Exp Ther. 1977 Mar;200(3):535-44.
Involvement of cholinergic presynaptic receptors of nicotinic and muscarinic types in the control of the spontaneous release of dopamine from striatal dopaminergic terminals in the rat.
Giorguieff MF, Le Floc'h ML, Glowinski J, Besson MJ.
Rat striatal slices (two) were superfused continuously with L-3,5-3H tyrosine and 3H-dopamine (3H-DA) release was estimated in serial fractions of superfusates. The spontaneous release of 3H-DA was reduced by about 50% when slices were superfused with a calcium-free medium containing ethylene glycol bis (beta-aminoethyl ether)- N,N'-tetraacetic acid (EGTA) (10(-4) M) or with a medium containg tetrodotoxin (5 x 10(-7) M). These effects were not related to a change in 3H-DA synthesis since the rate of L-3,5-3H tyrosine hydroxylation, as measured by 3H-H2O formation was not significantly reduced. Acetylcholine (ACh) (10(-5) M) stimulated the release of 3H-DA (about 100%). This effect was abolished in the absence of calcium; it was partially blocked by pempidine (10(-5) M), atropine (10(-6) M) or scopolamine (10(-5), 10(-6) M). Oxotremorine (10(-5) M) enhanced 3H-DA release but to a lesser extent (60%) than ACh (10(-5) M); its action was completely blocked by atropine (10(-6) M) and unaffected by pempidine (10(-5) M). The ACh- (10(-5) M) and oxotremorine- (10(-5) M) stimulatine effects on 3H-DA spontaneous release were still detected in slices superfused in the presence of tetrodotoxin (5 x 10(-7) M). In the presence of the neurotoxin, the effect of ACh (10(-5) M) was significantly reduced by pempidine (10(-5) M) and the effect of oxotremorine (10(-5) M) was blocked by atropine (10(-6) M). These results suggest the presence of cholinergic presynaptic receptors of the nicotinic and muscarinic types on striatal dopaminergic terminals.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=850127&dopt=Abstract
Indian J Exp Biol. 1991 Dec;29(12):1120-3.
Effect of a herbal psychotropic preparation, BR-16A (Mentat), on performance of mice on elevated plus-maze.
Verma A, Kulkarni SK.
Department of Pharmaceutical Sciences, Panjab University, Chandigarh, India.
Effect of BR-16A on various parameters of anxiety and transfer latency (TL) was studied in mice using elevated plus-maze. BR-16A (50-500 mg/kg) reduced the percentage of time spent in open arms and the percent preference of open arms for the first arm entry following acute as well as chronic drug administration. The total number of arm entries and the percentage of open arm entries remained unaffected. In combination with FG 7142 (10 mg/kg), BR-16A (100-500 mg/kg) further reduced the exploration of open arms. BR-16A reversed scopolamine (0.3 mg/kg)-induced delay in TL on 1st day. The reversal effect of BR-16A was enhanced by aniracetam (50 mg/kg). The data suggest anxiogenic and nootropic actions of BR-16A.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1816096&dopt=Abstract
Herbs and Pharmaceuticals Online ||
Hair Million herbal formula for hair loss and hair growth ||
Wellstreet online pharmacy for click-order prescription medications ||
Altace Online Pharmacy ||
Rx Drugs USA, Prescription Drugs Online Pharmacy ||
Insurance plans and information ||
Insurance policies for all purposes ||
Antibiotics and prescription medications online literature ||