Drugs online research references
Clin Pediatr (Phila). 1991 May;30(5):281-5.
Colic medication and apparent life-threatening events.
Hardoin RA, Henslee JA, Christenson CP, Christenson PJ, White M.
Southwest SIDS Research Institute, Lake Jackson, Texas 77566.
Eight infants with histories of apnea and cyanosis were referred to the Southwest SIDS Research Institute for evaluation of apparent life threatening events (ALTE). All of the infants had been treated for colic with a 1:1 concentration of dimenhydrinate (Dramamine) and phenobarbital, hyoscyamine sulfate, atropine sulfate and scopolamine hydrobromide (Donnatal). The medication was pre-mixed by local pharmacists. A comprehensive work-up failed to reveal a cause for the ALTE in any infant. The Dramamine/Donnatal mixture was withdrawn and polygraphic evaluation was conducted. Cardiorespiratory abnormalities were identified in all eight infants and significant gastroesophageal reflux (GER) was documented in four. The possibility that colic medication contributes to cardiorespiratory instability and GER in vulnerable infants requires serious consideration and further evaluation.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2044336&dopt=Abstract
Psychopharmacology (Berl). 1987;93(1):36-43.
Fluoxetine enhances memory processing in mice.
Flood JF, Cherkin A.
Fluoxetine (FLU) increases brain concentrations of serotonin by blocking its uptake, without appreciably affecting the dopamine or norepinephrine systems. The present experiments provide evidence that a subcutaneous injection of FLU enhanced post-memory processing ("consolidation") and retrieval, but not acquisition in young adult mice. FLU (15 mg/kg) enhanced 1-week memory retention when injected 2 min post-training. Similar enhancement was obtained with intracerebroventricular injection (20 micrograms per mouse). FLU enhanced retention when administered prior to training (1-5 mg/kg). FLU (2.5 mg/kg) enhanced recall scores when injected 1 h before the 1-week retention test, indicating an enhancing effect on memory retrieval. Neither the pre-training nor pre-testing effects depended on improved acquisition, since FLU did not improve acquisition of T-maze foot-shock avoidance over the dose range 0.5-35 mg/kg. The sensitive period for post-training enhancement by FLU (15 mg/kg) was less than 90 min, as shown by the temporal gradient typical of memory-enhancing drugs. The amnesia induced by a protein synthesis inhibitor anisomycin, or by an anticholinergic drug scopolamine, was blocked by FLU (15 mg/kg) injected post-training. Finally, FLU (15 mg/kg) injected after one-trial passive avoidance training enhanced 1-week retention, demonstrating effectiveness in this task as well as in the active avoidance task.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3114813&dopt=Abstract
Braz J Med Biol Res. 1981 Oct;14(4-5):281-4.
The effects of scopolamine pretreatment on stereotyped behavior induced by apomorphine in rats withdrawn from long-term haloperidol administration.
De-Souza H, Palermo-Neto J.
1. The effects of scopolamine on intensity of stereotyped behavior induced by the ED50 dose of apomorphine in controls and in animals withdrawn from long-term haloperidol treatment were studied. 2. Doses of 1.0 and 3.0 microgram/kg of scopolamine increased apomorphine-induced stereotypy in both groups. However, this increase was smaller in the haloperidol-treated than in the control animals. 3. These data support the hypothesis that long-term administration of haloperidol may produce a change not only in dopaminergic but also in central cholinergic receptor sensitivity.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7201335&dopt=Abstract
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