Drugs online research references
Nippon Yakurigaku Zasshi. 1985 Mar;85(3):129-41.
[TRH and its analog (DN-1417). Effects on central dopaminergic system-dependent behaviors in rats and mice]
[Article in Japanese]
Miyamoto M, Saji Y, Nagawa Y.
Effects of TRH and its analog, gamma-butyrolactone-gamma-carbonyl-histidyl-prolinamide citrate (DN-1417), on circling, stereotyped or climbing behavior were investigated in rats and mice. High doses of TRH (100 mg/kg, i.p.) and DN-1417 (20-50 mg/kg, i.p.) produced a significant ipsilateral circling behavior in rats with the lesions of the unilateral dopamine (DA) pathway by 6-hydroxydopamine. In intact mice, stereotyped sniffing accompanying hyperactivity was caused at low doses of TRH or DN-1417 (1-20 mg/kg, i.p.), and stereotyped licking behavior was observed at high doses of TRH or DN-1417 (20-200 mg/kg, i.p.). Furthermore, TRH, DN-1417 or methamphetamine caused a dose-related climbing behavior in mice pretreated with L-DOPA and Ro 4-4602. Circling behavior, stereotyped sniffing or licking behavior induced by TRH or DN-1417 was markedly suppressed by pretreatment with pimozide or alpha-methyltyrosine. However, atropine and scopolamine potentiated the circling inducing action of TRH or DN-1417, in contrast with suppression of the licking behavior. These results suggest that TRH and DN-1417 produce circling, sniffing, licking and climbing behaviors via activation of the central DA system, and that cholinergic mechanisms may be also involved in licking behavior induced by TRH or DN-1417.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3924793&dopt=Abstract
Braz J Med Biol Res. 1989;22(9):1155-8.
The cholinergic and dopaminergic systems of the prelimbic sector of frontal cortex and memory in the rat.
Brito GN, Silva SP, Brito LS.
Laboratorio de Neuropsicologia Experimental, Universidade Federal Fluminense, Niteroi, RJ, Brasil.
Rats were trained to perform delayed non-matching to sample (a working/representational memory task) and visual discrimination (a reference/dispositional memory task) in a T-maze, and implanted bilaterally with cannulae in the prelimbic cortex. The rats were tested postoperatively after bilateral 1-microliter injections of vehicle (Krebs-Ringer), sulpiride (10 micrograms/microliter) or scopolamine (18 micrograms/microliter). Sulpiride had no effect on the performance of either task, whereas scopolamine interfered only with the performance of delayed non-matching to sample. We conclude that dopaminergic mechanisms in the prelimbic cortex are not involved in either type of memory and that cholinergic, but not dopaminergic, mechanisms are important for working/representational memory processes.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2636012&dopt=Abstract
Neurosci Res. 1995 Jan;21(3):235-40.
Stimulatory effect of dopamine on acid secretion from the isolated rat stomach.
Tsai LH, Cheng JT.
Department of Physiology, Taipei Medical College, Taiwan, R.O.C.
The effect of dopamine (DA) on acid secretion was studied using the everted preparation of isolated rat stomachs. DA concentrations, measured by HPLC-ECD in the rumen, corpus and antrum were 1.06 nmol/mg protein, 0.49 nmol/mg protein and 2.92 nmol/mg protein, respectively. DA stimulated acid secretion at a concentration of 10 nM and elicited the maximum response at 10 microM, which was at a level approximately 1.56-fold that of the spontaneous secretion but only about half that of secretion induced by histamine at a concentration of 0.3 mM. The concentration-dependent stimulation by DA was antagonized by octopamine and SCH 23390. Failure of proglumide and cimetidine to affect this stimulation ruled out the participation of histamine and/or gastrin. Scopolamine and tetrodotoxin completely inhibited the acid secretion induced by low concentrations of DA but inhibited only partially the response induced by high concentrations of DA. The results obtained indicate that DA induces acid secretion via activation of the dopamine D1 receptor, located on the cholinergic neurons and on some nonneuronal cells, in the rat stomach.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7753504&dopt=Abstract
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