Drugs online research references
Psychopharmacology (Berl). 1978 Jul 19;58(3):311-5.
The effects of d-amphetamine and scopolamine on drinking induced by a multiple schedule.
Sanger DJ.
Three food-deprived rats obtained food pellets on a multiple fixed-interval fixed-time schedule. During fixed-interval components a 45 mg pellet was made available for a lever-press every minute (FI 1 min). When the fixed-time component was in operation the lever was retracted and a pellet was delivered every minute (FT 1 min) independent of behaviour. A water bottle was available to each subject and similar levels of schedule-induced drinking developed during the two schedule components. The effects of several doses (0.25, 0.5, 1.0, 2.0 mg/kg) of d-amphetamine and scopolamine were assessed on lever-pressing and drinking maintained by this procedure. Both drugs increased rates of lever-pressing at lower doses and reduced levels of licking and water intake at all doses. The patterning of fixed-interval lever pressing was altered by both drugs increasing the proportion of responses emitted during early parts of the intervals. d-Amphetamine also increased the proportion of licks that occurred during early segments of the interfood intervals, while scopolamine had variable effects on patterns of licking. There were no consistent differences in the effects of the drugs on licking induced by the two schedules.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=98803&dopt=Abstract
Br J Pharmacol. 1998 Dec;125(7):1562-6.
Involvement of 5-HT6 receptors in nigro-striatal function in rodents.
Bourson A, Boess FG, Bos M, Sleight AJ.
F. Hoffmann-La Roche Ltd., Preclinical Research, Pharma Division, Basle, Switzerland.
4-Amino-N-(2,4 bis-methylamino-pyrimidin-4-yl) benzene sulphonamide (Ro 04-6790) is a potent, selective and competitive antagonist for the 5-HT6 receptor which can be detected in the cerebro-spinal fluid (CSF) of rats following intraperitoneal administration. Since 5-HT6 receptor mRNA and 5-HT6 receptor-like immunoreactivity have been shown to be present in the striatum, the purpose of the present study was to evaluate the effect of 5-HT6 receptor antagonism on haloperidol- and SCH 23390-induced catalepsy in mice and on the turning behaviour of rats with unilateral 6-hydroxydopamine (6-OHDA) lesions of the medial forebrain bundle. Ro 04-6790 (3, 10 and 30 mg kg(-1) i.p.) did not induce catalepsy and had no effect on catalepsy induced by either haloperidol or SCH 23390. Ro 04-6790 (3, 10 and 30 mg kg(-1) i.p.) did not itself induce rotational behaviour in rats with unilateral 6-hydroxydopamine (6-OHDA) lesions of the medial forebrain bundle nor did it affect the rotational behaviour induced by either L-Dopa or amphetamine. 5-HT6 receptor antagonism inhibited the rotational behaviour of 6-OHDA lesioned rats induced by treatment with the muscarinic antagonists scopolamine and atropine. The data support earlier conclusions from experiments with antisense oligonucleotides that the 5-HT6 receptor is involved in the control of acetylcholine neurotransmission in the rat brain.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9884085&dopt=Abstract
J Pharm Biomed Anal. 1998 Sep 1;17(6-7):1167-76.
Validated capillary electrophoresis method for the determination of atropine and scopolamine derivatives in pharmaceutical formulations.
Cherkaoui S, Mateus L, Christen P, Veuthey JL.
Laboratory of Pharmaceutical Analytical Chemistry, University of Geneva, Switzerland.
The simultaneous determination of atropine and scopolamine derivatives, which have similar structures, was investigated by using capillary zone electrophoresis. The effects of buffer pH, buffer concentration and hydroxypropyl-beta-cyclodextrin concentration on migration time and resolution of the investigated compounds were systematically studied. The selected electrophoretic buffer consisted of a 80 mM sodium citrate pH 2.5, containing 2.5 mM hydroxypropyl-beta-cyclodextrin as the complexing agent. Quantitative analysis was validated by testing the reproducibility of the method, giving a relative standard deviation less than 1 and 2% for the intermediate precision of migration times and peak area ratios, respectively. The linearity of the method was assessed between 50 and 150% of the theoretical content (coefficient of correlation greater than 0.99). The proposed method was found to be suitable and accurate for the determination of these basic drugs in pharmaceutical preparations.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9884207&dopt=Abstract
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