Drugs online research references
Encephale. 1999 Jun;25 Spec No 2:29-31; discussion 32-5.
[Proofs of efficacy]
[Article in French]
Boyer P.
Centre Hospitalier Sainte-Anne, Paris.
Several factors are to be taken account in the assessment of the overall efficacy of a new antidepressant. There are rules governing the diagnostic categories, baseline scores and the conditions for the assessment of their course in the context of both placebo-controlled trials and studies versus reference products. As an illustration, two studies of clomipranine versus specific inhibitors of serotonin reuptake are reviewed. The author analyzes various studies conducted on venlafaxine, a new serotoninergic and noradrenergic product.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10434157&dopt=Abstract
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Psychopharmacology (Berl). 1999 Jun;144(4):355-62.
Chronic fluoxetine inhibits sexual behavior in the male rat: reversal with oxytocin.
Cantor JM, Binik YM, Pfaus JG.
Department of Psychology, McGill University, Montreal, Quebec, Canada.
RATIONALE: Selective serotonin reuptake inhibitors, used widely in the treatment of depression, progressively inhibit sexual orgasm in many patients and induce a transient inhibition of sexual desire. OBJECTIVES: We attempted to model the effects of these drugs in sexually experienced male rats during tests of copulation in bilevel chambers. These chambers allow the study of both appetitive and consummatory sexual responses of male rats. METHODS: Males were treated daily with fluoxetine hydrochloride (0, 1, 5, or 10 mg/kg) and tested for sexual behavior with receptive females at 4-day intervals. Rats were treated with oxytocin (200 ng/kg) or saline after ejaculations had decreased. RESULTS: Fluoxetine decreased ejaculatory responses of male rats in a dose- and time-dependent fashion, but left the copulatory efficiency of the males intact. In contrast, conditioned level changing, a measure of appetitive sexual excitement, was inhibited following acute and chronic treatment with 10 mg/kg, although tolerance may have developed to the effect of 5 mg/kg. Subsequent administration of oxytocin restored the ejaculatory response but not the measure of sexual excitement to baseline levels. CONCLUSIONS: The reversal by oxytocin of the fluoxetine-induced deficit in ejaculations is consistent with the hypothesis that serotonin suppresses ejaculatory mechanisms by interrupting the action of oxytocin, which normally accompanies sexual behavior. Co-administration of oxytocin may help to alleviate the predominant sexual side effect of serotonin reuptake blockers.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10435408&dopt=Abstract
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Horm Metab Res. 1999 Jun;31(6):363-6.
Decreased plasma leptin levels in lean and obese Zucker rats after treatment with the serotonin reuptake inhibitor fluoxetine.
Dryden S, Brown M, King P, Williams G.
Department of Medicine, University of Liverpool, UK.
Leptin inhibits feeding, stimulates thermogenesis and decreases body weight. Serotonin reduces food intake when injected into the hypothalamus and may interact with other neurotransmitters in the control of appetite. We therefore investigated the effects of the serotonergic drug fluoxetine, which inhibits serotonin reuptake, on food intake and plasma leptin levels in lean and obese Zucker rats. Fluoxetine significantly reduced food intake in lean and obese rats, both acutely after a single injection (10 mg/kg) and during continuous subcutaneous infusion (10 mg/kg/day for 7 days). Plasma leptin levels were reduced after both 4 hours and 7 days of fluoxetine administration in lean and after 7 days in fatty rats (all p<0.01). We have previously suggested that serotonin may decrease food intake by inhibiting neuropeptide Y neurones, and we further suggest that it also inhibits leptin, possibly by an effect on white adipose tissue.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10437624&dopt=Abstract
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