Drugs online research references
kaiser.alma.unibo.it
Some analytical methods (two spectrophotometric and two chromatographic procedures) for the determination of fluoxetine in Prozac capsules are described. All of them are applied to the samples after extracting the drug with a methanol water mixture. The direct and derivative spectrophotometric methods are simple and reliable; the derivative method gives better recovery and lessens interference. Both methods show linearity in the 5-30 microg ml(-1) range of the fluoxetine concentration range. Both HPLC methods (spectrophotometric and spectrofluorimetric detection) use a tetramethylammonium perchlorate buffer-acetonitrile mixture as the mobile phase and a C8 reversed phase column. The UV detection is performed at 226 nm, while the fluorimetric detection is performed by exciting at 230 nm and revealing the emission at 290 nm. The HPLC method with UV detection is more precise, but the procedure with fluorimetric detection is more sensitive.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9919971&dopt=Abstract
note: kwd match prozac online literature
Int J Eat Disord. 1999 Jan;25(1):39-44.
Prior treatment received by patients with bulimia nervosa.
Crow S, Mussell MP, Peterson C, Knopke A, Mitchell J.
Department of Psychiatry, University of Minnesota, Minneapolis 55455, USA.
OBJECTIVE: This study examined the frequency with which subjects with bulimia nervosa (BN) presenting for treatment or follow-up studies had previously received either adequate pharmacologic treatment or cognitive-behavioral therapy (CBT). METHOD: Semistructured telephone screening of individuals who called in response to advertisements about research studies was used to establish diagnoses and to clarify prior pharmacologic and psychotherapeutic treatments for BN. RESULTS: Of 581 women responding, 353 (60.8%) had probable BN. Overall, 61.4% of these subjects had received psychotherapy (96.7%) but rarely CBT (6.9%). Over one half (63.7%) had received pharmacologic treatment, most commonly with fluoxetine (72.5%). Of those having received any medication treatment, 46.2% were judged to have received at least one adequate trial. Overall, 35.0% of those previously treated had received at least one prior course of adequate pharmacotherapy or CBT for BN. CONCLUSION: Although efficacious treatments for BN have been established, they have not been received by most individuals presenting for further treatment.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9924651&dopt=Abstract
note: kwd match prozac online literature
J Psychoactive Drugs. 1998 Oct-Dec;30(4):367-9.
Ayahuasca preparations and serotonin reuptake inhibitors: a potential combination for severe adverse interactions.
Callaway JC, Grob CS.
Department of Pharmaceutical Chemistry, University of Kuopio, Finland.
The Amazonian psychoactive plant beverage ayahuasca has attracted increasing interest in recent years. Little attention has been given, however, to potentially dangerous interactions with other drugs. In particular, the interaction between the potent monoamine oxidase-inhibiting harmala alkaloids in ayahuasca and the selective serotonin reuptake inhibitor (SSRI) class of antidepressants may induce a serotonin syndrome with potentially grave outcome. Caution is advised when combining ayahuasca with certain pharmaceutical drugs.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9924842&dopt=Abstract
note: kwd match prozac online literature
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