Drugs online research references
Aust N Z J Psychiatry. 1998 Apr;32(2):295-8.
Hyponatraemia associated with the use of selective serotonin re-uptake inhibitors.
Strachan J, Shepherd J.
Department of Psychiatry and Behavioural Science, Auckland University, New Zealand.
OBJECTIVE: The aim of this study is to examine the frequency and severity of hyponatraemia in a psychogeriatric inpatient population taking selective serotonin re-uptake inhibitors (SSRIs). METHOD: Casenotes for 1 year were reviewed and 53 patients with 55 admissions were identified. Eighteen were treated with fluoxetine and 37 with paroxetine. Five (28%) of the patients on fluoxetine and eight (22%) on paroxetine were, or became, hyponatraemic. RESULTS: The SSRI was discontinued in two symptomatic patients. Serum sodium returned to normal in nine patients maintained on the SSRI. Two patients maintained on an SSRI remained hyponatraemic but asymptomatic. CONCLUSIONS: Hyponatraemia may be a relatively common early asymptomatic side effect of SSRIs, especially in older women. Serum sodium should be measured before commencing an SSRI and monitored during the first month. Any patient who exhibits symptoms of hyponatraemia, or whose depression apparently worsens, while on an SSRI must have their serum sodium measured. Discontinuation of the SSRI may be avoidable if serum sodium levels can be closely monitored.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9588311&dopt=Abstract
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Zh Nevrol Psikhiatr Im S S Korsakova. 1997;97(12):32-4.
[Choice of therapeutic tactics in treatment of endogenous depression by means of statusmetric expert system]
[Article in Russian]
Vovin RIa, Mazo GE, Razorenova TS, Razorenov GI.
There was elaborated expert models based on computer data base including 42 formalized signs (anamnesis, state of the patients, medical measures and indices of expert estimation of the response to therapy, based on the reduction of scores of Hamilton's scale). The study was carried out in 104 in-patients whose clinical states corresponded according to ICD-10 to category "depressive episode" and "recurrent depressive disorder". The patients were divided into 2 groups: in the first one the treatment was performed by serotoninergic antidepressants (SA)-fluoxetine (20 patients), fluvoxamine (20), sertraline (30). Tricyclic antidepressant (TAD) amitryptiline was administered to 34 patients of the second group. Two data bases were formed: responders to TAD and responders to SA. Natural pair model of classification (error of the model--12.5%) including 9 informative signs, was constructed, that gave chance to define probability sensitivity to TAD and SA. Check-up of computer model revealed that 3 patients of SA group didn't submit to decisive rule, while there were found 2 such patients in TAD application. Application of computer experiment permitted to turn from group prognosis to individual one.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9591062&dopt=Abstract
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Eur J Pharmacol. 1998 Mar 12;345(1):35-9.
Selective serotonin reuptake inhibitors potentiate 8-OH-DPAT-induced stimulus control in the pigeon.
Wolff MC, Leander JD.
Lilly Research Laboratories, Eli Lilly, Lilly Corporate Center, Indianapolis, IN 46285, USA.
The effects of two selective serotonin reuptake inhibitors, fluoxetine and citalopram, and a nonselective monoamine reuptake inhibitor, imipramine, were characterized in pigeons that had been trained to discriminate 0.64 mg/kg of 8-hydroxy-(2-di-n-propylamino)tetralin hydrobromide (8-OH-DPAT), a 5-HT1A receptor agonist, from saline. Neither fluoxetine, citalopram, nor imipramine generalized to the 8-OH-DPAT-induced stimulus cue. However, when administered in addition to 8-OH-DPAT, both fluoxetine (10 mg/kg) and citalopram (10 mg/kg) lowered the ED50 for generalization of 8-OH-DPAT from 0.16 mg/kg (8-OH-DPAT by itself) to 0.05 mg/kg (fluoxetine + 8-OH-DPAT) and 0.06 mg/kg (citalopram + 8-OH-DPAT). Under similar conditions, imipramine (1 mg/kg) had no effect on the generalization curve for 8-OH-DPAT. The data support the hypothesis that activation of the 5-HT1A receptor may be relevant to the mechanism of action of serotonin reuptake inhibitors.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9593591&dopt=Abstract
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