Drugs online research references
Bioorg Med Chem Lett. 2002 Mar 11;12(5):811-5.
Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 2: 4-substituted 6-nitroquipazines.
Se Lee B, Chu S, Lee BS, Yoon Chi D, Song YS, Jin C.
Department of Chemistry, Inha University, 253 Yonghyundong, Namgu, 402-751, Inchon, Republic of Korea
Eleven 4-substituted derivatives of 6-nitroquipazine were synthesized and evaluated for their abilities to displace [3H]citalopram binding to the rat cortical synaptic membranes. Among them, 4-chloro-6-nitroquipazine was shown to possess the highest binding affinity (K(i=)0.03 nM) which was approximately 6 times higher than that of 6-nitroquipazine (K(i)=0.17 nM) itself. In this paper, we describe the syntheses of 4-substituted 6-nitroquipazine derivatives, the results of corresponding biological evaluation and the SAR study.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11859009&dopt=Abstract
note: kwd match prozac online literature
terra.com.br
RATIONALE: Several antidepressants attenuate conditioned escape behaviours reinforced by the terminus of an electrical stimulus applied to the dorsal periaqueductal grey (DPAG). OBJECTIVE: The present study examined whether the antidepressant and antipanic drugs clomipramine (CLM) and fluoxetine (FLX) also attenuate the DPAG-evoked unconditioned defensive behaviours. METHODS: Rats with electrodes in the DPAG were electrically stimulated in the absence of any treatment or 30 min after injections of CLM, FLX or saline. Threshold functions of cumulative response frequencies were fitted through the logistic model and compared using likelihood ratio coincidence tests. RESULTS: CLM produced non-linear effects on galloping, for which median thresholds (I50) were significantly increased (19 +/- 2%) or decreased (22+/-2%) with 5 mg/kg and 10 mg/kg, respectively, or did not change with 20 mg/kg. The latter dose further increased the I(50) of micturition (38 +/- 1%) and decreased the defecation output (-33 +/- 15%). FLX significantly increased the I50 of immobility (22 +/- 2%) and galloping (25 +/- 3%) with 1 mg/kg and 5 mg/kg, respectively. Moreover, corresponding doses either decreased the maximum output (-25 +/- 13%) or increased the I50 (56 +/- 11%) of defecation. Saline was ineffective. CONCLUSIONS: While the attenuation of defecation and micturition by 20 mg/kg CLM suggests a peripheral antimuscarinic action, CLM non-linear effects on galloping were most likely due to its differential action on monoaminergic and cholinergic central mechanisms. In contrast, the attenuation of immobility, galloping and defecation by low doses of FLX suggests a serotonin-mediated antiaversive action. Finally, CLM and FLX acute effects on DPAG-evoked unconditioned galloping response were strikingly similar to those reported for DPAG-evoked shuttle-box conditioned escape.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11862341&dopt=Abstract
note: kwd match prozac online literature
Electrophoresis. 2002 Feb;23(3):442-8.
Nonaqueous capillary electrophoresis-electrospray- mass spectrometry for the analysis of fluoxetine and its related compounds.
Cherkaoui S, Veuthey JL.
Laboratory of Pharmaceutical Analytical Chemistry, University of Geneva, Geneva, Switzerland.
The potential of nonaqueous capillary electrophoresis was investigated for the simultaneous separation of fluoxetine hydrochloride, its meta-isomer, and other related compounds. The resolution of these compounds was compared in aqueous and nonaqueous media. Baseline separation of the studied solutes required a buffer electrolyte solution composed of 25 mM ammonium acetate and 1 M acetic acid in acetonitrile, an applied voltage of 30 kV and a temperature of 20 degrees C. Selectivity was considerably affected by the nature of the solvent (water, methanol, and acetonitrile). Moreover, substituting acetate by formate in the background electrolyte resulted in migration time changes, which were attributed to an ion-pairing phenomenon. Finally, the method was successfully coupled on-line with electrospray ionization-mass spectrometry (ESI-MS) and allowed significant selectivity and sensitivity enhancement. The effect of ESI-MS parameters, such as nebulizing gas pressure, sheath liquid composition and flow rate, on resolution and method sensitivity was also discussed.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11870746&dopt=Abstract
note: kwd match prozac online literature
Herbs and Pharmaceuticals Online ||
Hair Million herbal formula for hair loss and hair growth ||
Antibiotics and prescription medications online literature ||