Drugs online research references
Indian J Exp Biol. 1996 Mar;34(3):211-5.
A lethal cardiotoxic protein isolated from Bidder's organ of common Indian toad, Bufo melanostictus Schneider.
Gomes A, Alam MI, Muhuri DC, Auddy B, Dasgupta SC.
Department of Physiology, University of Calcutta, India.
A lethal cardiotoxic (BO-CT; Bidder's organ cardiotoxin) protein was purified from the Bidder's organ of the common Indian toad B. melanostictus by gel filtration on Sephadex G-200. The homogeneity of cardiotoxin was tested by gel electrophoresis. The molecular weight of lethal BO-CT was 62 KDa and was devoid of glycoprotein. LD50 of the BO-CT was 50 micrograms/20 g (i.v.) in male albino mice. On isolated heart and auricle BO-CT initially increased the rate and amplitude of contraction and finally produced irreversible blockade of contraction. BO-CT induced auricular blockade, was not influenced by verapamil, propranolol and atropine. On isolated chick biventer cervicis preparation BO-CT produced irreversible blockade of electrically induced twitch response followed by contracture. This action was not antagonized by 4-aminopyridine and neostigmine. BO-CT induced contracture on chick biventer cervicis was increased by Ca2+, decreased by Na+ and abolished by K+. Cardiotoxic and neuromuscular activity of BO-CT was heat stable and abolished by proteolytic enzyme.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8781032&dopt=Abstract
J Pharmacol Exp Ther. 1996 Mar;276(3):1155-61.
Ontogenic differences in the functions of myocardial alpha1 adrenoceptor subtypes in rats.
Deng XF, Chemtob S, Almazan G, Varma DR.
Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada.
The present study was done to determine possible ontogenic differences in the functions of rat myocardial alpha1, adrenoceptor (alpha1 AR) subtypes in view of reported greater inotropic responses of myocardium of neonatal than of adult rats to alpha1, AR agonists. Methoxamine, phenylephrine and norepinephrine were used as alpha1 AR agonists. Phenylephrine and norepinephrine were used in the presence of 3 microM propranolol. It was found that the ratios of chloroethylclonidine (CEC)-insensitive alpha1 AR subtype (alpha1A AR) to CES-sensitive alpha, AR subtype (alpha1B AR) were approximately 50:50 in neonatal (1 week old) and 20:80 in adult rat ventricles. alpha1A AR selective antagonists WB 4101 and 5-methylurapidil+ (5-MU) inhibited the inotropic effects of alpha1, AR agonists both on neonatal and on adult rat ventricles; in contrast, selective inactivation of alpha1B AR by CEC inhibited the inotropic effects of alpha1 AR agonists only on ventricles from adult but not from neonatal animals. WB 4101 inhibited methoxamine-induced increases in inositol phosphates by ventricular slices from both adult and neonatal rats; in contrast, CEC inhibited these effects of methoxamine only in tissues from adult but not in tissues from neonatal animals. In conclusion, this study, to our knowledge, demonstrates for the first time that the effects of alpha AR agonists on right ventricular contractions and phosphoinositol turnover are mediated primarily by alpha 1A AR subtype in the neonatal and by both alpha1A AR and alpha1B AR subtypes in the adult rat.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8786547&dopt=Abstract
Clin Exp Hypertens. 1979;1(6):713-31.
The effects of long term oral treatment with indapamide on the development of DOCA-salt hypertension in rats: vascular reactivity studies.
Hicks PE.
The onset of DOCA-salt hypertension in male Sprague-Dawley rats was prevented during 11 weeks of oral treatment with indapamide (0.5, or 10.0 mg/kg) or propranolol (60 mg/kg) administered in the diet. The body weights of the indapamide treated groups were significantly (P < 0.01) greater, at weeks 4, 5, 6, 7 and 11, while the body weights and food intake of the propranolol treated group were significantly (P < 0.05) lower at week 11, than the control group. A significant reduction in heart wet weight (P < 0.001) was measured in the indapamide treated animals only. No significant diuresis nor natriuresis was measured in any group during week 11 of treatment. When all groups were subjected to an increased salt load, four weeks after cessation of drug treatment only the indapamide (10 mg/kg) treated animals failed to show an increased blood pressure. Vascular reactivity studies carried out six weeks after termination of drug treatment, indicated a significant (P < 0.01) reduction in pressor activity elicited by electrical stimulation of the entire sympathetic outflow in indapamide (10 mg/kg) treated pithed rats. No significant difference in the pressor activity elicited by noradrenaline (5 x 10(-8) - 5 x 10(-6) g/kg, i.v.) or tyramine (10(-5) - 5 x 10(-5) g/kg i.v.) was observed in any treatment group. In conclusion, chronic oral treatment with indapamide or propranolol, prevented the onset of DOCA-salt hypertension in rats. A long lasting antihypertensive action of indapamide involving the sympathetic nervous system is also indicated.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=551896&dopt=Abstract
Herbs and Pharmaceuticals Online ||
Hair Million herbal formula for hair loss and hair growth ||
Wellstreet online pharmacy for click-order prescription medications ||
Altace Online Pharmacy ||
Rx Drugs USA, Prescription Drugs Online Pharmacy ||
Insurance plans and information ||
Insurance policies for all purposes ||
Antibiotics and prescription medications online literature ||