Drugs online research references
Psychopharmacology (Berl). 1985;86(1-2):153-5.
Effects of d,l-propranolol on open field behavior of rats.
Poli A, Palermo-Neto J.
Rats were administered with different doses of d,l-propranolol or d,l-propranolol plus amphetamine before open-field observations. Results show that d,l-propranolol decreased locomotion and rearing frequencies and increased immobility duration in rats. An antagonism between the effects of amphetamine and d,l-propranolol on general activity of rats was also observed. Results are discussed in the light of a possible interference of the drugs with the activity of either noradrenergic neurons or mid-brain reticular formation.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3927351&dopt=Abstract
ahabs.wise.edu
We examined the functional role of adrenergic receptor subtypes (ARs) in bovine intra-mammary arteries (IMAs), 1.5-2.5 mm internal diameter. Norepinephrine (NE) and phenylephrine (PE) produced concentration-dependent increases in tone in segments maintained at a previously determined optimal basal tension in vitro. The sensitivity of the tissue to NE and PE, based on -log molar ED50s was 6.87 +/- 0.17 and 7.05 +/- 0.35, respectively. In addition a Schild analysis yielded antagonist affinities for the receptor mediating contractile responses to NE (pA2 value) of 10.46 +/- 0.85 for prazosin and 6.29 +/- 0.18 for yohimbine. These data indicate a dominance of functional alpha 1 (alpha(1)) over alpha 2 (alpha(2))-ARS in this tissue. Based on the inhibitory effects of chloroethylclonidine (CEC) on PE responses and the further reduction in sensitivity when nifedipine was added to the CEC, also in the presence of PE, we conclude that there is more than one alpha(1)-AR subtype, with a predominant role for alpha(1B)-ARs in phenylephrine responses. Stimulation of beta (beta)-ARs, resulted in relatively small reductions in tone (the highest magnitude of response was 25.94 +/- 6.46% of the papaverine maximum at 3 x 10(-6) M isoproterenol); in addition, propranolol did not significantly alter tissue sensitivity to NE. Additional characterization of functional autonomic receptor populations in this circulatory bed will form a basis for future studies on circulatory dynamics in the mammary gland.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9430766&dopt=Abstract
J Chromatogr A. 1993 Oct 22;652(2):451-7.
Effect of buffer solution pH on the elution and separation of beta-blockers by micellar electrokinetic capillary chromatography.
Lukkari P, Vuorela H, Riekkola ML.
Department of Chemistry, University of Helsinki, Finland.
Study was made of the effect of the pH of phosphate buffer (0.08 M) containing 15 mM cetyltrimethylammonium bromide as surfactant on the elution order of eleven widely used beta-adrenergic blocking agents. In the pH range 6.0-7.8 the elution order of six of the beta-blockers remained the same, while the order of five of them changed. Sotalol eluted as the sixth compound at pH 6.8 and migrated more quickly with increasing pH. Below pH 7.0 labetalol eluted before propranolol and above pH 7.0 afterwards. Likewise, the order of elution of atenolol and timolol was reversed at pH 7.0. The pH also affected the resolution; the best resolution values were achieved between pH 6.6 and 7.0 and between pH 7.4 and 7.8. The relationship between the structure of the beta-blockers described by molecular and molecular connectivity indices and the elution order and separation of the beta-blockers in micellar electrokinetic capillary chromatography at varying pH of the buffer solution is discussed.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7904519&dopt=Abstract
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